SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits

Toda, T., Cameron, S., Sass, P., Wigler, M. H. (May 1988) SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev, 2 (5). pp. 517-27. ISSN 0890-9369

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URL: https://www.ncbi.nlm.nih.gov/pubmed/3290050

DOI: 10.1101/gad.2.5.517

Abstract

A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation. Sequence analysis indicates that it encodes a 90,000-dalton protein with a carboxy-terminal domain homologous to yeast and mammalian cAMP-dependent protein kinase catalytic subunits. In addition to suppressing loss of CDC25 function, multicopy plasmids containing SCH9 suppress the growth defects of strains lacking the RAS genes, the CYR1 gene, which encodes adenylyl cyclase, and the TPK genes, which encode the cAMP-dependent protein kinase catalytic subunits. Cells lacking SCH9 grow slowly and have a prolonged G1 phase of the cell cycle. This defect is suppressed by activation of the cAMP effector pathway. We propose that SCH9 encodes a protein kinase that is part of a growth control pathway which is at least partially redundant with the cAMP pathway.

Item Type:	Paper
Additional Information:
Uncontrolled Keywords:	Amino Acid Sequence Base Sequence Catalysis Gene Expression Regulation Genes Fungal Molecular Sequence Data Plasmids Protein Kinases genetics Saccharomyces cerevisiae genetics Sequence Homology Nucleic Acid Suppression Genetic
Subjects:	bioinformatics > genomics and proteomics > annotation > gene expression profiling annotation organism description > yeast > Saccharomyces bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
CSHL Authors:	Wigler, Michael H.
Communities:	CSHL labs > Wigler lab
Depositing User:	CSHL Librarian
Date:	May 1988
Date Deposited:	05 Apr 2012 19:34
Last Modified:	07 Nov 2016 19:35
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/25997

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