Items where Subject is "therapies"

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Number of items at this level: 62.

A

Adams, B., Golding, S., Biddlestone-Thorpe, L., Beckta, J., Saleh, H., Enikopolov, G., Valerie, K. (2011) In Vivo and In Vitro Human Brain Tumor Models for Improving the Therapeutic Ratio of Ionizing Radiation and DNA Repair Inhibitors. International Journal of Radiation Oncology Biology Physics, 81 (S2). S741-S742. ISSN 0360-3016

Andersen, J. N., Tonks, N. K. (2004) Protein tyrosine phosphatase-based therapeutics- lessons from PTP1B. In: Protein phosphatases. Topics in current genetics, 5 . Springer-Verlag, Berlin, pp. 201-230. ISBN 3540205608

B

Bell, D. W., Sordella, R., Kwak, E. L., Godin-Heymann, N., Sharma, S. V., Sgroi, D. C., Sequist, L. V., Lynch, T. J., Settleman, J., Haber, D. A. (2006) Molecular targeted therapy of lung cancer. Tumor Biology, 27 (Suppl). ISSN 1010-4283

Bordeleau, M. E., Robert, F., Gerard, B., Lindqvist, L., Chen, S. M., Wendel, H. G., Brem, B., Greger, H., Lowe, S. W., Porco, J. A., Pelletier, J. (2008) Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model. J Clin Invest, 118 (7). 2651- 2660.

Burgess, D. J., Doles, J., Zender, L., Xue, W., Ma, B., McCombie, W. R., Hannon, G. J., Lowe, S. W., Hemann, M. T. (2008) Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proc Natl Acad Sci U S A, 105 (25). pp. 9053-9058.

C

Chen, M., Nowak, D. G., Trotman, L. C. (2014) Molecular Pathways: PI3K Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy. Clinical Cancer Research, 20 (12). pp. 3057-63. ISSN 1078-0432

Crockford, A., Jamal-Hanjani, M., Hicks, J., Swanton, C. (2014) Implications of intratumour heterogeneity for treatment stratification. Journal of Pathology, 232 (2). pp. 264-273. ISSN 00223417 (ISSN)

E

Eifert, C., Powers, R. S. (2012) From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets. Nat Rev Cancer, 12 (8). pp. 572-578. ISSN 1474-1768 (Electronic)1474-175X (Linking)

Ellis, L., Lindemann, R., Newbold, A., Whitecross, K., Cluse, L., Pelligrini, M., Wei, A., Scott, C., Atadja, P., Lowe, S. W., Johnstone, R. W. (2007) Characterization of the apoptotic and therapeutic activities of the histone deacetylase inhibitors LAQ824 and LBH589 using a mouse model of B cell lymphoma. Molecular Cancer Therapeutics, 6 (12 Par). 3475S-3476S. ISSN 1535-7163

F

Fernandez, Y., Verhaegen, M., Miller, T. P., Rush, J. L., Steiner, P., Opipari, A. W., Lowe, S. W., Soengas, M. S. (2005) Differential regulation of noxa in normal Melanocytes and melanoma cells by proteasome inhibition: Therapeutic implications. Cancer Research, 65 (14). pp. 6294-6304. ISSN 0008-5472

G

Galluzzi, L., Vacchelli, E., Bravo-San Pedro, J., Buque, A., Senovilla, L., Baracco, E. E., Bloy, N., Castoldi, F., Abastado, J., Agostinis, P., Apte, R. N., Aranda, F., Ayyoub, M., Beckhove, P., Blay, J., Bracci, L., Caignard, A., Castelli, C., Cavallo, F., Celis, E., Cerundolo, V., Clayton, A., Colombo, M. P., Coussens, L., Dhodapkar, M. V., Eggermont, A. M., Fearon, D. T., Fridman, W. H., Fucikova, J., Gabrilovich, D. I., Galon, J., Garg, A., Ghiringhelli, F., Giaccone, G., Gilboa, E., Gnjatic, S., Hoos, A., Hosmalin, A., Jager, D., Kalinski, P., Karre, K., Kepp, O., Kiessling, R., Kirkwood, J. M., Klein, E., Knuth, A., Lewis, C. E., Liblau, R., Lotze, M. T., Lugli, E., Mach, J., Mattei, F., Mavilio, D., Melero, I., Melief, C. J., Mittendorf, E. A., Moretta, L., Odunsi, A., Okada, H., Palucka, A. K., Peter, M. E., Pienta, K. J., Porgador, A., Prendergast, G. C., Rabinovich, G. A., Restifo, N. P., Rizvi, N., Sautes-Fridman, C., Schreiber, H., Seliger, B., Shiku, H., Silva-Santos, B., Smyth, M. J., Speiser, D. E., Spisek, R., Srivastava, P. K., Talmadge, J. E., Tartour, E., Van Der Burg, S. H., Van Den Eynde, B. J., Vile, R., Wagner, H., Weber, J. S., Whiteside, T. L., Wolchok, J. D., Zitvogel, L., Zou, W., Kroemer, G. (2014) Classification of current anticancer immunotherapies. Oncotarget, 5 (24). ISSN 1949-2553

Gerhard, D. S., Clemons, P. A., Shamji, A. F., Hon, C., Wagner, B. K., Schreiber, S. L., Krasnitz, A., Sordella, R., Sander, C., Lowe, S. W., Powers, S., Smith, K., Aburi, M., Iavarone, A., Lasorella, A., Silva, J., Stockwell, B. R., Califano, A., Boehm, J. S., Vazquez, F., Weir, B. A., Hahn, W. C., Khuri, F. R., Moreno, C. S., Johns, M., Fu, H., Nikolova, O., Mendez, E., Gadi, V. K., Margolin, A. A., Grandori, C., Kemp, C. J., Warren, E. H., Riddell, S. R., McIntosh, M. W., Gevaert, O., Kuo, C. J., Ji, H. P., Dhruv, H., Finlay, D., Kiefer, J., Kim, S., Vuori, K., Berens, M. E., Hangauer, M., Boettcher, M., Weissman, J. S., Bivona, T. G., Bandyopadhyay, S., McManus, M. T., McCormick, F., Aksoy, O., Simonds, E. F., Zheng, T., Chen, J., An, Z., Balmain, A., Weiss, W. A., Chen, K., Liang, H., Scott, K. L., Mills, G. B., Posner, B. A., MacMillan, J., Minna, J., White, M., Roth, M. G., Jagu, S., Mazerik, J. (2016) Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Mol Cancer Res. ISSN 1557-3125 (Electronic)1541-7786 (Linking)

Gingeras, T. R., Prodanovich, P., Latimer, T., Guatelli, J. C., Richman, D. D., Barringer, K. J. (1991) Use of self-sustained sequence replication amplification reaction to analyze and detect mutations in zidovudine-resistant human immunodeficiency virus. Journal of Infectious Diseases, 164 (6). pp. 1066-1074. ISSN 00221899 (ISSN)

Guix, M., de Matos Granja, N., Meszoely, I., Adkins, T. B., Wieman, B. M., Frierson, K. E., Sanchez, V., Sanders, M. E., Grau, A. M., Mayer, I. A., Pestano, G., Shyr, Y., Muthuswamy, S., Calvo, B., Krontiras, H., Krop, I. E., Kelley, M. C., Arteaga, C. L. (2008) Short Preoperative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor Positive Breast Cancers. J Clin Oncol, 26 (6). pp. 897-906.

H

Hein, N., Bywater, M. J., Stanley, K., Verbrugge, I., Cullinane, C., Baker, A., Zuber, H., Rappaport, A., Drygin, D., Huser, N., Bliesath, J., Ryckman, D. M., Rice, W. G., Lowe, S. W., Johnstone, R. W., Pearson, R. B., McArthur, G. A., Hannan, R. D. (2011) Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias. Blood, 118 (21). p. 673. ISSN 0006-4971

Herrmann, H., Blatt, K., Shi, J. W., Rappaport, A. R., Gleixner, K. V., Cerny-Reiterer, S., Peter, B., Wang, E., Sperr, W. R., Bradner, J. E., Lowe, S. W., Vakoc, C. R., Zuber, J., Valent, P. (2011) Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML. Blood, 118 (21). p. 1487. ISSN 0006-4971

K

Kani, K., Sordella, R., Mallick, P. (2012) Investigation of acquired resistance to EGFR-targeted therapies in lung cancer using cDNA microarrays. Methods in Molecular Biology, 795. pp. 233-53. ISSN 1940-6029 (Electronic)1064-3745 (Linking)

Kole, R., Krainer, A. R., Sullenger, B. (2010) RNA & OLIGONUCLEOTIDE THERAPEUTICS. In: 2010 meeting on RNA & OLIGONUCLEOTIDE THERAPEUTICS, April 7–April 10, 2010, Cold Spring Harbor.

Kozal, M. J., Shah, N., Shen, N., Yang, R., Fucini, R., Merigan, T. C., Richman, D. D., Morris, D., Hubbell, E., Chee, M., Gingeras, T. R. (1996) Extensive polymorphisms observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nature Medicine, 2 (7). pp. 753-759. ISSN 10788956 (ISSN)

Kozal, M. J., Shah, N., Yang, R., Shen, N., Fucini, R., Merigan, T. C., Richman, D. D., Chee, M. S., Gingeras, T. R. (1995) Natural polymorphism of HIV-1 clade B protease gene and implications for therapy. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 10 (S3). p. 76. ISSN 1077-9450

Krainer, A. (2012) Pre-mRNA Splicing Mechanisms, Misregulation in Disease, and Therapeutic Strategies. Blood, 120 (21). ISSN 0006-4971

L

Leduc, P. R., Wong, M. S., Ferreira, P. M., Groff, R. E., Haslinger, K., Koonce, M. P., Lee, W. Y., Love, J. C., McCammon, J. A., Monteiro-Riviere, N. A., Rotello, V. M., Rubloff, G. W., Westervelt, R., Yoda, M. (2007) Towards an in vivo biologically inspired nanofactory. Nature Nanotechnology, 2 (1). pp. 3-7. ISSN 1748-3387

Lindemann, R., Newbold, A., Whitecross, K., Cluse, L., Frew, A., Ellis, L., Williams, S., Wiegmans, A., Dear, A., Scott, C., Pelligrini, M., Wei, A., Richon, V., Marks, P., Lowe, S. W., Smyth, M., Johnstone, R. (2008) Defining the apoptotic pathways underlying HDAC inhibitor-mediated tumor therapy in vivo. Onkologie, 31 (Suppl.). pp. 69-70. ISSN 0378-584X

Lu, P., Liu, F., Yan, L., Peng, T., Liu, T., Yao, Z., Wang, C. Y. (2007) Stem cells therapy for type 1 diabetes. Diabetes Research and Clinical Practice, 78 (1). pp. 1-7. ISSN 0168-8227

Lucito, R. (2011) Talk from Rob Lucito at the Cold Spring Harbor Laboratory In-House Symposium (2011). [Video] (Unpublished)

Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., Louis, D. N., Christiani, D. C., Settleman, J., Haber, D. A. (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. The New England Journal of Medicine, 350 (21). pp. 2129-39. ISSN 1533-4406 (Electronic)

Lyon, Gholson J. (2013) Advancing Precision Medicine through clinical grade whole genome sequencing, return of results and deep brain stimulation. [Video] (Unpublished)

M

MacDiarmid, J. A., Mugridge, N. B., Weiss, J. C., Phillips, L., Burn, A. L., Paulin, R. P., Haasdyk, J. E., Dickson, K. A., Brahmbhatt, V. N., Pattison, S. T., James, A. C., Al Bakri, G., Straw, R. C., Stillman, B., Graham, R. M., Brahmbhatt, H. (2007) Bacterially derived 400 nm particles for encapsulation and cancer cell targeting of chemotherapeutics. Cancer Cell, 11 (5). pp. 431-445. ISSN 1535-6108

McDermott, U., Sharma, S. V., Dowell, L., Greninger, P., Montagut, C., Lamb, J., Archibald, H., Raudales, R., Tam, A., Lee, D., Rothenberg, S. M., Supko, J. G., Sordella, R., Ulkus, L. E., Iafrate, A. J., Maheswaran, S., Njauw, C. N., Tsao, H., Drew, L., Hanke, J. H., Ma, X. J., Erlander, M. G., Gray, N. S., Haber, D. A., Settleman, J. (2007) Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proceedings of the National Academy of Sciences of the United States of America, 104 (50). pp. 19936-41. ISSN 0027-8424

Mirrione, M. M., Li, B., Henn, F. A. (2011) Lateral Habenula Circuit Activity Following High Frequency Deep Brain Stimulation. Biological Psychiatry, 69 (9). 127S-128S. ISSN 0006-3223

Muthuswamy, S. K. (2011) Trastuzumab resistance: all roads lead to SRC. Nature Medicine, 17 (4). pp. 416-8. ISSN 1078-8956

N

Narita, M., Lowe, S. W. (2005) Senescence comes of age. Nature Medicine, 11 (9). pp. 920-922. ISSN 1078-8956

Neesse, A., Frese, K. K., Chan, D. S., Bapiro, T. E., Howat, W. J., Richards, F. M., Ellenrieder, V., Jodrell, D. I., Tuveson, D. A. (2013) SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut, 63 (6). pp. 974-983. ISSN 00175749 (ISSN)

O

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. Supplementary video of subject M.A for Integrating precision medicine in the study and clinical treatment of a severely mentally ill person. PeerJ 1:e177. [Video]

O'Rawe, Jason, Fang, Han, Rynearson, Shawn, Robison, Reid J., Kiruluta, Edward S., Higgins, Gerald, Eilbeck, Karen, Reese, Martin G., Lyon, Gholson J. (2013) Integrating precision medicine in the study and clinical treatment of a severely mentally ill person. PeerJ, 1. e177.

Osten, P. (2012) Talk from Pavel Osten at the Cold Spring Harbor Laboratory In-House Symposium (2012). [Video] (Unpublished)

R

Rapp, S., Baader, M., Hu, M., Jennen-Steinmetz, C., Henn, F. A., Thome, J. (2004) Differential regulation of synaptic vesicle proteins by antidepressant drugs. Pharmacogenomics J, 4 (2). pp. 110-3. ISSN 1470-269X (Print)1470-269X (Linking)

Robert, F., Carrier, M., Rawe, S., Chen, S., Lowe, S. W., Pelletier, J. (2009) Altering chemosensitivity by modulating translation elongation. PLoS ONE, 4 (5). e5428.

S

Sartorius, A., Henn, F. A. (2005) [Continuation ECT]. Psychiatr Prax, 32 (8). pp. 408-11. ISSN 0303-4259 (Print)0303-4259 (Linking)

Sartorius, A., Henn, F. A. (2007) Deep brain stimulation of the lateral habenula in treatment resistant major depression. Med Hypotheses, 69 (6). pp. 1305-8. ISSN 0306-9877 (Print)0306-9877 (Linking)

Sartorius, A., Krier, A., Andres, F. J., Bender, H. J., Krumm, B., Henn, F. A. (2006) Bispectral index monitoring for more effective electroconvulsive therapy? Br J Anaesth, 96 (6). pp. 806-7. ISSN 0007-0912 (Print)0007-0912 (Linking)

Sartorius, A., Munoz-Canales, E. M., Krumm, B., Krier, A., Andres, F. J., Bender, H. J., Henn, F. A. (2006) ECT anesthesia: the lighter the better? Pharmacopsychiatry, 39 (6). pp. 201-4. ISSN 0176-3679 (Print)0176-3679 (Linking)

Sartorius, A., Vollmayr, B., Neumann-Haefelin, C., Ende, G., Hoehn, M., Henn, F. A. (2003) Specific creatine rise in learned helplessness induced by electroconvulsive shock treatment. Neuroreport, 14 (17). pp. 2199-201. ISSN 0959-4965 (Print)0959-4965 (Linking)

Sawey, E. T., Chanrion, M., Cai, C., Wu, G., Zhang, J., Zender, L., Zhao, A., Busuttil, R. W., Yee, H., Stein, L. D., French, D. M., Finn, Richard S, Lowe, S. W., Powers, S. (2011) Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening. Cancer Cell, 19 (3). pp. 347-358. ISSN 1535-6108

Schloss, P., Henn, F. A. (2004) New insights into the mechanisms of antidepressant therapy. Pharmacol Ther, 102 (1). pp. 47-60. ISSN 0163-7258 (Print)0163-7258 (Linking)

Schmitt, C. A., Fridman, J. S., Yang, M., Lee, S., Baranov, E., Hoffman, R. M., Lowe, S. W. (2002) A senescence program controlled by p53 and p16(INK4a) contributes to the outcome of cancer therapy. Cell, 109 (3). pp. 335-346. ISSN 0092-8674

Scott, R., Bourtchuladze, R., Gossweiler, S., Dubnau, J. T., Tully, T. (2002) CREB and the discovery of cognitive enhancers. Journal of Molecular Neuroscience, 19 (1-2). pp. 171-177. ISSN 0895-8696

Silva, J. M., Hammond, S. M., Hannon, G. J. (2002) RNA interference: A promising approach to antiviral therapy? Trends in Molecular Medicine, 8 (11). pp. 505-508. ISSN 14714914 (ISSN)

Smolen, G. A., Sordella, R., Muir, B., Mohapatra, G., Barmettler, A., Archibald, H., Kim, W. J., Okimoto, R. A., Bell, D. W., Sgroi, D. C., Christensen, J. G., Settleman, J., Haber, D. A. (2006) Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proceedings of the National Academy of Sciences of the United States of America, 103 (7). pp. 2316-21. ISSN 0027-8424

Stewart, D., Stillman, B. (2005) Molecular Approaches to Controlling Cancer. In: Cold Spring Harbor Symposia on Quantitative Biology LXX: Molecular Approaches to Controlling Cancer, Cold Spring Harbor.

Szabo, K., Hirsch, J. G., Krause, M., Ende, G., Henn, F. A., Sartorius, A., Gass, A. (2007) Diffusion weighted MRI in the early phase after electroconvulsive therapy. Neurol Res, 29 (3). pp. 256-9. ISSN 0161-6412 (Print)0161-6412 (Linking)

W

Wang, G. H., Krishnamurthy, K., Tangpisuthipongsa, D. (2011) Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. Journal of Neurochemistry, 117 (4). pp. 703-711. ISSN 0022-3042

Watson, J. (2013) Oxidants, antioxidants and the current incurability of metastatic cancers. Open Biology, 3 (1). pp. 2046-2441.

Watson, J. D. (2011) Curing "incurable" Cancer. Cancer Discovery, 1 (6). pp. 477-480. ISSN 2159-8274

Winters, M. A., Shafer, R. W., Jellinger, R. A., Mamtora, G., Gingeras, T. R., Merigan, T. C. (1997) Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. Antimicrobial Agents and Chemotherapy, 41 (4). pp. 757-762. ISSN 0066-4804

Witkowski, J. A. (1996) 'Nothing to laugh at at all': humor in biochemical journals. Trends in Biochemical Sciences, 21 (4). pp. 156-60. ISSN 0968-0004 (Print)

Wolf, J., Sartorius, A., Alm, B., Henn, F. A. (2004) Clozapine-induced lupus erythematosus. J Clin Psychopharmacol, 24 (2). pp. 236-8. ISSN 0271-0749 (Print)0271-0749 (Linking)

Y

Yao, Z., Fenoglio, S., Gao, D. C., Camiolo, M., Stiles, B., Lindsted, T., Schlederer, M., Johns, C., Altorki, N., Mittal, V., Kenner, L., Sordella, R. (2010) TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Proceedings of the National Academy of Sciences of the United States of America, 107 (35). pp. 15535-40. ISSN 0027-8424

Young, J. D., Lawrence, A. J., MacLean, A. G., Leung, B. P., McInnes, I. B., Canas, B., Pappin, D. J., Stevenson, R. D. (1999) Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids. Nature Medicine, 5 (12). pp. 1424-7. ISSN 1078-8956 (Print)1078-8956 (Linking)

Yuneva, M., Zamboni, N., Oefner, P., Sachidanandam, R., Lazebnik, Y. (2007) Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol, 178 (1). pp. 93-105. ISSN 0021-9525 (Print)

Z

Zink, M., Henn, F. A., Thome, J. (2004) Combination of amisulpride and olanzapine in treatment-resistant schizophrenic psychoses. Eur Psychiatry, 19 (1). pp. 56-8. ISSN 0924-9338 (Print)0924-9338 (Linking)

Zink, M., Knopf, U., Henn, F. A., Thome, J. (2004) Combination of clozapine and amisulpride in treatment-resistant schizophrenia--case reports and review of the literature. Pharmacopsychiatry, 37 (1). pp. 26-31. ISSN 0176-3679 (Print)0176-3679 (Linking)

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