ECT anesthesia: the lighter the better?

Sartorius, A., Munoz-Canales, E. M., Krumm, B., Krier, A., Andres, F. J., Bender, H. J., Henn, F. A. (November 2006) ECT anesthesia: the lighter the better? Pharmacopsychiatry, 39 (6). pp. 201-4. ISSN 0176-3679 (Print)0176-3679 (Linking)

DOI: 10.1055/s-2006-950395


BACKGROUND: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated. METHODS: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. RESULTS: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p=0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. CONCLUSION: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.

Item Type: Paper
Uncontrolled Keywords: Aged Anesthesia Depressive Disorder, Major/psychology/therapy Electroconvulsive Therapy Electroencephalography/ drug effects Female Heart Rate/physiology Humans Male Middle Aged Psychiatric Status Rating Scales Regression Analysis
Subjects: diseases & disorders > mental disorders
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: November 2006
Date Deposited: 01 Mar 2013 17:27
Last Modified: 01 Mar 2013 17:27
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