Sartorius, A., Munoz-Canales, E. M., Krumm, B., Krier, A., Andres, F. J., Bender, H. J., Henn, F. A. (November 2006) ECT anesthesia: the lighter the better? Pharmacopsychiatry, 39 (6). pp. 201-4. ISSN 0176-3679 (Print)0176-3679 (Linking)
Abstract
BACKGROUND: Electroconvulsive therapy (ECT) is a most effective treatment for patients with major affective disorders. The influence of anesthetic drugs on seizure "adequacy" or on treatment success has not been systematically investigated. METHODS: A bispectral EEG index score (BIS) was used to identify the depth of anesthesia during ECT. Our study included 22 major depressive episode (MDE) patients expanding to 219 ECTs (05/05-01/06) with no limitations of concurrent medication. RESULTS: Fourteen out of the 22 patients showed full remission. Individual number of ECT sessions needed to reach full remission correlated negatively with mean pre-ECT BIS values (p=0.001). Additionally, using a repeated measurement regression analysis significant correlations were found for pre-ECT BIS versus motor response time, seizure concordance, ictal coherence and peak heart rate. CONCLUSION: The results of our study suggest BIS-levels as a predictor of faster ECT response. Controlling BIS-levels before stimulation may have an additional effect on treatment success.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Aged Anesthesia Depressive Disorder, Major/psychology/therapy Electroconvulsive Therapy Electroencephalography/ drug effects Female Heart Rate/physiology Humans Male Middle Aged Psychiatric Status Rating Scales Regression Analysis |
| Subjects: | diseases & disorders > mental disorders therapies |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | November 2006 |
| Date Deposited: | 01 Mar 2013 17:27 |
| Last Modified: | 01 Mar 2013 17:27 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27660 |
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