Molecular Approaches to Controlling Cancer

Stewart, D., Stillman, B. (2005) Molecular Approaches to Controlling Cancer. In: Cold Spring Harbor Symposia on Quantitative Biology LXX: Molecular Approaches to Controlling Cancer, Cold Spring Harbor.

DOI: 10.1101/sqb.2005.70.060


During the past quarter century or so, much effort has been devoted toward the understanding of the molecular basis of cancer. We now understand that cancer is primarily a genetic disease of mutations in the tumor genome acquired over a lifetime. The products of oncogenes and tumor suppressor genes have been placed into pathways of gene networks that are altered in tumor cells compared to normal cells in tissue. Furthermore, we also understand that tumors function as abnormal organs, forming an architecture of a number of different cell types and recruiting a blood supply, albeit an irregular one. There have been many Symposia in this series that dealt with cancer directly, and even more that focused on basic biology that contributed greatly to understanding cancer. As a result of some interesting developments in cancer diagnosis and therapy over the past five years, it was appropriate that a Symposium be devoted for the first time to molecular approaches to cancer therapy. Several examples now exist of targeted therapy that works in patients that have been profiled based on genetic diagnosis of the patient’s tumor. Additionally, therapies targeting the tumor as an organ, such as anti-angiogenic therapy, are now used in the clinic with modest success. The hope is that this type of molecular approach to cancer therapy will accelerate and become more effective in the future.

Item Type: Conference or Workshop Item (Paper)
Subjects: diseases & disorders > cancer
diseases & disorders
diseases & disorders > cancer > drugs and therapies
CSHL Authors:
Communities: CSHL labs > Stillman lab
Meetings and Courses
Depositing User: Matt Covey
Date: 2005
Date Deposited: 03 Mar 2014 20:05
Last Modified: 21 Jan 2015 16:45

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