Items where Community is "CSHL labs > Helfman lab"

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Bakin, A. V., Safina, A., Rinehart, C., Daroqui, C., Darbary, H., Helfman, D. M. (2004) A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells. Molecular Biology of the Cell, 15 (10). pp. 4682-4694. ISSN 1059-1524

Kim, E. J., Helfman, D. M. (2003) Characterization of the metastasis-associated protein, S100A4 - Roles of calcium binding and dimerization in cellular localization and interaction with myosin. Journal of Biological Chemistry, 278 (32). pp. 30063-30073. ISSN 0021-9258

Pawlak, G., Helfman, D. M. (2002) Anchorage-independent activation of ERK1/2 depends on myosin light chain kinase-mediated regulation of myosin II. Molecular Biology of the Cell, 13. 158A-158A. ISSN 1059-1524

Pawlak, G., Helfman, D. M. (2002) MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. Journal of Biological Chemistry, 277 (30). pp. 26927-26933. ISSN 0021-9258

Pawlak, G., Helfman, D. M. (2002) Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Molecular Biology of the Cell, 13 (1). pp. 336-347. ISSN 1059-1524

Araya, E., Berthier, C., Kim, E., Yeung, T., Wang, X. R., Helfman, D. M. (2002) Regulation of coiled-coil assembly in tropomyosins. Journal of Structural Biology, 137 (1-2). pp. 176-183. ISSN 1047-8477

Pawlak, G., Helfman, D. M. (2001) Activation of MEK mediates v-Src induced disruption of the actin cytoskeleton. Molecular Biology of the Cell, 12. 51A-51A. ISSN 1059-1524

Lee, S., Helfman, D. M. (2001) Regulation of caldesmon expression and function in normal and Ras-transformed fibroblasts. Molecular Biology of the Cell, 12. 51A-51A. ISSN 1059-1524

Connell, L. E., Helfman, D. M. (2001) Role of actin and myosin in apoptosis in normal and Ras-transformed MDCK cells. Molecular Biology of the Cell, 12. 194A-195A. ISSN 1059-1524

Pawlak, G., Helfman, D. M. (2001) Cytoskeletal changes in cell transformation and tumorigenesis. Current Opinion in Genetics & Development, 11 (1). pp. 41-47. ISSN 0959-437X

Sung, L. A., Gao, K. M., Yee, L. J., Temm-Grove, C. J., Helfman, D. M., Lin, J. J. C., Mehrpouryan, M. (2000) Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons. Blood, 95 (4). pp. 1473-1480. ISSN 0006-4971

Helfman, D. M., Levy, E. T., Berthier, C., Shtutman, M., Riveline, D., Grosheva, I., Lachish-Zalait, A., Elbaum, M., Bershadsky, A. D. (1999) Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. Molecular Biology of the Cell , 10 (10). pp. 3097-112. ISSN 1059-1524 (Print)

Chen, C. D., Kobayashi, R., Helfman, D. M. (1999) Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes and Development, 13 (5). pp. 593-606. ISSN 0890-9369 (Print)

Selvakumar, M., Helfman, D. M. (1999) Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA. Rna, 5 (3). pp. 378-94. ISSN 1355-8382 (Print)

Chen, C. D., Helfman, D. M. (1999) Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA. Rna, 5 (2). pp. 290-301. ISSN 1355-8382 (Print)

Helfman, D. M., Berthier, C., Grossman, J., Leu, M., Ehler, E., Perriard, E., Perriard, J. C. (1999) Nonmuscle tropomyosin-4 requires coexpression with other low molecular weight isoforms for binding to thin filaments in cardiomyocytes. Journal of Cell Science, 112 ( . pp. 371-80. ISSN 0021-9533 (Print)

Grossman, J. S., Meyer, M. I., Wang, Y. C., Mulligan, G. J., Kobayashi, R., Helfman, D. M. (1998) The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. Rna, 4 (6). pp. 613-25. ISSN 1355-8382 (Print)

Temm-Grove, C. J., Jockusch, B. M., Weinberger, R. P., Schevzov, G., Helfman, D. M. (1998) Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions. Cell Motility and the Cytoskeleton, 40 (4). pp. 393-407. ISSN 0886-1544 (Print)

Berthier, C., Blaineau, S. (1997) Supramolecular organization of the subsarcolemmal cytoskeleton of adult skeletal muscle fibers. A review. Biology of the Cell, 89 (7). pp. 413-34. ISSN 0248-4900

Gimona, M., Lando, Z., Dolginov, Y., Vandekerckhove, J., Kobayashi, R., Sobieszek, A., Helfman, D. M. (1997) Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. Journal of Cell Science, 110 ( . pp. 611-21. ISSN 0021-9533

Gimona, M., Kazzaz, J. A., Helfman, D. M. (1996) Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proceedings of the National Academy of Sciences, 93 (18). pp. 9618-23. ISSN 0027-8424 (Print)

Watakabe, A., Kobayashi, R., Helfman, D. M. (1996) N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. Journal of Cell Science, 109 (Pt 9). pp. 2299-310. ISSN 0021-9533

Temm-Grove, C. J., Guo, W., Helfman, D. M. (1996) Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Cell Motility and the Cytoskeleton, 33 (3). pp. 223-40. ISSN 0886-1544 (Print)

Temm-Grove, C. J., Guo, W., Helfman, D. M. (1996) Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Cell Motil Cytoskeleton, 33 (3). pp. 223-40. ISSN 0886-1544 (Print)

Gimona, M., Watakabe, A., Helfman, D. M. (1995) Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Proc Natl Acad Sci U S A, 92 (21). pp. 9776-80. ISSN 0027-8424 (Print)

Balvay, L., Pret, A. M., Libri, D., Helfman, D. M., Fiszman, M. Y. (1994) Splicing of the Alternative Exons of the Chicken, Rat, and Xenopus Beta-Tropomyosin Transcripts Requires Class-Specific Elements. Journal of Biological Chemistry, 269 (31). pp. 19675-19678. ISSN 0021-9258

Tsukahara, T., Casciato, C., Helfman, D. M. (1994) Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res, 22 (12). pp. 2318-25. ISSN 0305-1048 (Print)

Stamm, S., Zhang, M. Q., Marr, T. G., Helfman, D. M. (1994) A sequence compilation and comparison of exons that are alternatively spliced in neurons. Nucleic Acids Res, 22 (9). pp. 1515-26. ISSN 0305-1048 (Print)

Schrader, M., Temmgrove, C. J., Lessard, J. L., Jockusch, B. M. (1994) Chicken Antibodies to Rabbit Muscle Actin with a Restricted Repertoire of F-Actin Recognition. European Journal of Cell Biology, 63 (2). pp. 326-335. ISSN 0171-9335

Pittenger, M. F., Kazzaz, J. A., Helfman, D. M. (1994) Functional properties of non-muscle tropomyosin isoforms. Curr Opin Cell Biol, 6 (1). pp. 96-104. ISSN 0955-0674 (Print)

Helfman, D. M. (1994) The generation of protein isoform diversity by alternative RNA splicing. Soc Gen Physiol Ser, 49. pp. 105-15. ISSN 0094-7733 (Print)

Helfman, D. M. (1993) Generation of Protein Isoform Diversity by Alternative Rna Splicing. Journal of General Physiology, 102 (6). A5-A5. ISSN 0022-1295

Stamm, S., Casper, D., Lees-Miller, J. P., Helfman, D. M. (1993) Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain. Proc Natl Acad Sci U S A, 90 (21). pp. 9857-61. ISSN 0027-8424 (Print)

Guo, W., Helfman, D. M. (1993) Cis-Elements Involved in Alternative Splicing in the Rat Beta-Tropomyosin Gene - the 3'-Splice Site of the Skeletal-Muscle Exon-7 Is the Major Site of Blockage in Nonmuscle Cells. Nucleic Acids Res, 21 (20). pp. 4762-4768. ISSN 0305-1048

Novy, R. E., Liu, L. F., Lin, C. S., Helfman, D. M., Lin, J. J. C. (1993) Expression of Smooth-Muscle and Nonmuscle Tropomyosins in Escherichia-Coli and Characterization of Bacterially Produced Tropomyosins. Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology, 1162 (3). pp. 255-265. ISSN 0006-3002

Mulligan, G. J., Guo, W., Wormsley, S., Helfman, D. M. (1992) Polypyrimidine Tract Binding-Protein Interacts with Sequences Involved in Alternative Splicing of Beta-Tropomyosin Premessenger Rna. Journal of Biological Chemistry, 267 (35). pp. 25480-25487. ISSN 0021-9258

Stamm, S., Casper, D., Dinsmore, J., Kaufmann, C. A., Brosius, J., Helfman, D. M. (1992) Clathrin light chain B: gene structure and neuron-specific splicing. Nucleic Acids Res, 20 (19). pp. 5097-103. ISSN 0305-1048 (Print)0305-1048 (Linking)

Lees-Miller, J. P., Helfman, D. M., Schroer, T. A. (1992) A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature, 359 (6392). pp. 244-6. ISSN 0028-0836 (Print)0028-0836 (Linking)

Schroer, T. A., Heuser, J. E., Helfman, D. M., Leesmiller, J. P. (1992) Actin-Rpv - the Major Component of the Dynactin Complex - Activator of Cytoplasmic Dynein. Molecular Biology of the Cell, 3. A2-A2. ISSN 1059-1524

Pittenger, M. F., Helfman, D. M. (1992) In vitro and in vivo characterization of four fibroblast tropomyosins produced in bacteria: TM-2, TM-3, TM-5a, and TM-5b are co-localized in interphase fibroblasts. J Cell Biol, 118 (4). pp. 841-58. ISSN 0021-9525 (Print)0021-9525 (Linking)

Lees-Miller, J. P., Henry, G., Helfman, D. M. (1992) Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin. Proc Natl Acad Sci U S A, 89 (1). pp. 80-3. ISSN 0027-8424 (Print)0027-8424 (Linking)

Guo, W., Mulligan, G. J., Wormsley, S., Helfman, D. M. (1991) Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells. Genes Dev, 5 (11). pp. 2096-107. ISSN 0890-9369 (Print)0890-9369 (Linking)

Helfman, D. M., Guo, W., Lees-Miller, J. P., Mulligan, G. J., Tsukahara, T., Wormsley, S. (1991) Alternative Rna Splicing in the Control of Cytoskeletal Protein Gene-Expression. Journal of Muscle Research and Cell Motility, 12 (5). p. 487. ISSN 0142-4319

Lees-Miller, J. P., Helfman, D. M. (1991) The molecular basis for tropomyosin isoform diversity. Bioessays, 13 (9). pp. 429-37. ISSN 0265-9247 (Print)0265-9247 (Linking)

Goodwin, L. O., Lees-Miller, J. P., Leonard, M. A., Cheley, S. B., Helfman, D. M. (1991) Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters. J Biol Chem, 266 (13). pp. 8408-15. ISSN 0021-9258 (Print)0021-9258 (Linking)

Helfman, D. M., Guo, W., Mulligan, G. J., Tsukahara, T., Wormsley, S. (1991) Alternative Rna Splicing in the Control of Gene Expression. Journal of Cellular Biochemistry, 47 (Suppl ). p. 15.

Guo, W., Helfman, D. M. (1991) Alternative Rna Splicing of Beta Tropomyosin Pre-Messenger Rna Identification of Exon and Intron Elements That Inhibit the Use of the Skeletal Muscle-Specific Exon in Nonmuscle Cells. Journal of Cellular Biochemistry, 47 (Suppl ). p. 73.

Krainer, A. R., Mayeda, A., Helfman, D., Conway, G. C., Kozak, D. (1991) Biochemistry of Mammalian Nuclear Pre-Messenger Rna Splicing and Splice Site Selection. Journal of Cellular Biochemistry, 47 (Suppl ). p. 45.

Lees-Miller, J. P., Helfman, D. M. (1991) Identification and Analysis of an Essential Gene Encoding a Distinctive Actin-Like Protein from Schizosaccharomyces-Pombe. Journal of Cell Biology, 115 (3 PART). 159A.

Pittenger, M. F., Helfman, D. M. (1991) Localization of Tropomyosin Isoforms in Non-Muscle Cells. Journal of Cell Biology, 115 (3 PART). 378A.

Kazzaz, J. A., Helfman, D. M. (1991) Transcriptional Regulation of the Beta Tropomyosin Gene. Journal of Cellular Biochemistry, 47 (Suppl ). p. 74.

Lees-Miller, J. P., Yan, A., Helfman, D. M. (1990) Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4. J Mol Biol, 213 (3). pp. 399-405. ISSN 0022-2836 (Print)0022-2836 (Linking)

Lees-Miller, J. P., Goodwin, L. O., Helfman, D. M. (1990) Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing. Mol Cell Biol, 10 (4). pp. 1729-42. ISSN 0270-7306 (Print)0270-7306 (Linking)

Helfman, D. M., Roscigno, R. F., Mulligan, G. J., Finn, L. A., Weber, K. S. (1990) Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA. Genes Dev, 4 (1). pp. 98-110. ISSN 0890-9369 (Print)0890-9369 (Linking)

Pittenger, M., Kistler, A., Helfman, D. (1990) The Role of Tropomyosin Diversity in Cellular Function. Journal of Cell Biology, 111 (5 PART). 305A.

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