Supramolecular organization of the subsarcolemmal cytoskeleton of adult skeletal muscle fibers. A review

Berthier, C., Blaineau, S. (October 1997) Supramolecular organization of the subsarcolemmal cytoskeleton of adult skeletal muscle fibers. A review. Biology of the Cell, 89 (7). pp. 413-34. ISSN 0248-4900

DOI: 10.1016/S0248-4900(97)89313-6


This review is focused on the composition and organization of the junctional subsarcolemmal cytoskeleton of adult muscle fibers. The cytoskeleton of muscle fibers is organized in functionally distinct compartments and the subsarcolemmal cytoskeleton itself can be broadly divided into junctional (myotendinous junction, neuromuscular junction and costameres) and non-junctional domains. In junctional zones three different multimolecular cytoskeletal complexes coexist: the focal adhesion-type, the spectrin-based and the dystrophin vs utrophin-based membrane skeleton systems. These complexes extend over several levels, from intracytoplasmic to subsarcolemmal and transmembranous; their common feature is the anchorage of actin filaments emanating from the intracytoplasmic level. The different cytoskeletal proteins, their putative roles and their interactions with various signaling pathways are presented here in detail. The subsarcolemmal cytoskeleton complexes are thought to play distinct physiological roles (membrane stabilization, force transmission to extracellular matrix, ionic channel anchorage, etc) but their colocalization on the three sarcolemmal junctional domains strongly suggests interrelated or common functions.

Item Type: Paper
Uncontrolled Keywords: Adult Animals Cytoskeletal Proteins/ physiology Cytoskeleton/ metabolism/ ultrastructure Humans Muscle, Skeletal/metabolism/ ultrastructure Sarcolemma/ultrastructure
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > animal > developmental stage > adult
organism description > animal
organism description > animal > mammal > primates > hominids > human
CSHL Authors:
Communities: CSHL labs > Helfman lab
Depositing User: Kathleen Darby
Date: October 1997
Date Deposited: 07 May 2014 15:45
Last Modified: 07 May 2014 15:45
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