Items where Community is "Helfman lab"

Paper

Bakin, A. V., Safina, A., Rinehart, C., Daroqui, C., Darbary, H., Helfman, D. M. (October 2004) A critical role of tropomyosins in TGF-beta regulation of the actin cytoskeleton and cell motility in epithelial cells. Molecular Biology of the Cell, 15 (10). pp. 4682-4694. ISSN 1059-1524

Kim, E. J., Helfman, D. M. (August 2003) Characterization of the metastasis-associated protein, S100A4 - Roles of calcium binding and dimerization in cellular localization and interaction with myosin. Journal of Biological Chemistry, 278 (32). pp. 30063-30073. ISSN 0021-9258

Pawlak, G., Helfman, D. M. (November 2002) Anchorage-independent activation of ERK1/2 depends on myosin light chain kinase-mediated regulation of myosin II. Molecular Biology of the Cell, 13. 158A-158A. ISSN 1059-1524

Pawlak, G., Helfman, D. M. (July 2002) MEK mediates v-Src-induced disruption of the actin cytoskeleton via inactivation of the Rho-ROCK-LIM kinase pathway. Journal of Biological Chemistry, 277 (30). pp. 26927-26933. ISSN 0021-9258

Pawlak, G., Helfman, D. M. (January 2002) Post-transcriptional down-regulation of ROCKI/Rho-kinase through an MEK-dependent pathway leads to cytoskeleton disruption in Ras-transformed fibroblasts. Molecular Biology of the Cell, 13 (1). pp. 336-347. ISSN 1059-1524

Araya, E., Berthier, C., Kim, E., Yeung, T., Wang, X. R., Helfman, D. M. (January 2002) Regulation of coiled-coil assembly in tropomyosins. Journal of Structural Biology, 137 (1-2). pp. 176-183. ISSN 1047-8477

Pawlak, G., Helfman, D. M. (November 2001) Activation of MEK mediates v-Src induced disruption of the actin cytoskeleton. Molecular Biology of the Cell, 12. 51A-51A. ISSN 1059-1524

Lee, S., Helfman, D. M. (November 2001) Regulation of caldesmon expression and function in normal and Ras-transformed fibroblasts. Molecular Biology of the Cell, 12. 51A-51A. ISSN 1059-1524

Connell, L. E., Helfman, D. M. (November 2001) Role of actin and myosin in apoptosis in normal and Ras-transformed MDCK cells. Molecular Biology of the Cell, 12. 194A-195A. ISSN 1059-1524

Pawlak, G., Helfman, D. M. (February 2001) Cytoskeletal changes in cell transformation and tumorigenesis. Current Opinion in Genetics & Development, 11 (1). pp. 41-47. ISSN 0959-437X

Sung, L. A., Gao, K. M., Yee, L. J., Temm-Grove, C. J., Helfman, D. M., Lin, J. J. C., Mehrpouryan, M. (February 2000) Tropomyosin isoform 5b is expressed in human erythrocytes: implications of tropomodulin-TM5 or tropomodulin-TM5b complexes in the protofilament and hexagonal organization of membrane skeletons. Blood, 95 (4). pp. 1473-1480. ISSN 0006-4971

Helfman, D. M., Levy, E. T., Berthier, C., Shtutman, M., Riveline, D., Grosheva, I., Lachish-Zalait, A., Elbaum, M., Bershadsky, A. D. (October 1999) Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. Molecular Biology of the Cell , 10 (10). pp. 3097-112. ISSN 1059-1524 (Print)

Chen, C. D., Kobayashi, R., Helfman, D. M. (March 1999) Binding of hnRNP H to an exonic splicing silencer is involved in the regulation of alternative splicing of the rat beta-tropomyosin gene. Genes and Development, 13 (5). pp. 593-606. ISSN 0890-9369 (Print)

Selvakumar, M., Helfman, D. M. (March 1999) Exonic splicing enhancers contribute to the use of both 3' and 5' splice site usage of rat beta-tropomyosin pre-mRNA. Rna, 5 (3). pp. 378-94. ISSN 1355-8382 (Print)

Chen, C. D., Helfman, D. M. (February 1999) Donor site competition is involved in the regulation of alternative splicing of the rat beta-tropomyosin pre-mRNA. Rna, 5 (2). pp. 290-301. ISSN 1355-8382 (Print)

Helfman, D. M., Berthier, C., Grossman, J., Leu, M., Ehler, E., Perriard, E., Perriard, J. C. (February 1999) Nonmuscle tropomyosin-4 requires coexpression with other low molecular weight isoforms for binding to thin filaments in cardiomyocytes. Journal of Cell Science, 112 ( . pp. 371-80. ISSN 0021-9533 (Print)

Grossman, J. S., Meyer, M. I., Wang, Y. C., Mulligan, G. J., Kobayashi, R., Helfman, D. M. (June 1998) The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points. Rna, 4 (6). pp. 613-25. ISSN 1355-8382 (Print)

Temm-Grove, C. J., Jockusch, B. M., Weinberger, R. P., Schevzov, G., Helfman, D. M. (1998) Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions. Cell Motility and the Cytoskeleton, 40 (4). pp. 393-407. ISSN 0886-1544 (Print)

Berthier, C., Blaineau, S. (October 1997) Supramolecular organization of the subsarcolemmal cytoskeleton of adult skeletal muscle fibers. A review. Biology of the Cell, 89 (7). pp. 413-34. ISSN 0248-4900

Gimona, M., Lando, Z., Dolginov, Y., Vandekerckhove, J., Kobayashi, R., Sobieszek, A., Helfman, D. M. (March 1997) Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. Journal of Cell Science, 110 ( . pp. 611-21. ISSN 0021-9533

Gimona, M., Kazzaz, J. A., Helfman, D. M. (September 1996) Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proceedings of the National Academy of Sciences, 93 (18). pp. 9618-23. ISSN 0027-8424 (Print)

Watakabe, A., Kobayashi, R., Helfman, D. M. (September 1996) N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. Journal of Cell Science, 109 (Pt 9). pp. 2299-310. ISSN 0021-9533

Temm-Grove, C. J., Guo, W., Helfman, D. M. (1996) Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Cell Motility and the Cytoskeleton, 33 (3). pp. 223-40. ISSN 0886-1544 (Print)

Temm-Grove, C. J., Guo, W., Helfman, D. M. (1996) Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Cell Motil Cytoskeleton, 33 (3). pp. 223-40. ISSN 0886-1544 (Print)

Gimona, M., Watakabe, A., Helfman, D. M. (October 1995) Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Proc Natl Acad Sci U S A, 92 (21). pp. 9776-80. ISSN 0027-8424 (Print)

Balvay, L., Pret, A. M., Libri, D., Helfman, D. M., Fiszman, M. Y. (August 1994) Splicing of the Alternative Exons of the Chicken, Rat, and Xenopus Beta-Tropomyosin Transcripts Requires Class-Specific Elements. Journal of Biological Chemistry, 269 (31). pp. 19675-19678. ISSN 0021-9258

Tsukahara, T., Casciato, C., Helfman, D. M. (June 1994) Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res, 22 (12). pp. 2318-25. ISSN 0305-1048 (Print)

Stamm, S., Zhang, M. Q., Marr, T. G., Helfman, D. M. (May 1994) A sequence compilation and comparison of exons that are alternatively spliced in neurons. Nucleic Acids Res, 22 (9). pp. 1515-26. ISSN 0305-1048 (Print)

Schrader, M., Temmgrove, C. J., Lessard, J. L., Jockusch, B. M. (April 1994) Chicken Antibodies to Rabbit Muscle Actin with a Restricted Repertoire of F-Actin Recognition. European Journal of Cell Biology, 63 (2). pp. 326-335. ISSN 0171-9335

Pittenger, M. F., Kazzaz, J. A., Helfman, D. M. (February 1994) Functional properties of non-muscle tropomyosin isoforms. Curr Opin Cell Biol, 6 (1). pp. 96-104. ISSN 0955-0674 (Print)

Helfman, D. M. (1994) The generation of protein isoform diversity by alternative RNA splicing. Soc Gen Physiol Ser, 49. pp. 105-15. ISSN 0094-7733 (Print)

Helfman, D. M. (December 1993) Generation of Protein Isoform Diversity by Alternative Rna Splicing. Journal of General Physiology, 102 (6). A5-A5. ISSN 0022-1295

Stamm, S., Casper, D., Lees-Miller, J. P., Helfman, D. M. (November 1993) Brain-specific tropomyosins TMBr-1 and TMBr-3 have distinct patterns of expression during development and in adult brain. Proc Natl Acad Sci U S A, 90 (21). pp. 9857-61. ISSN 0027-8424 (Print)

Guo, W., Helfman, D. M. (October 1993) Cis-Elements Involved in Alternative Splicing in the Rat Beta-Tropomyosin Gene - the 3'-Splice Site of the Skeletal-Muscle Exon-7 Is the Major Site of Blockage in Nonmuscle Cells. Nucleic Acids Res, 21 (20). pp. 4762-4768. ISSN 0305-1048

Novy, R. E., Liu, L. F., Lin, C. S., Helfman, D. M., Lin, J. J. C. (March 1993) Expression of Smooth-Muscle and Nonmuscle Tropomyosins in Escherichia-Coli and Characterization of Bacterially Produced Tropomyosins. Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology, 1162 (3). pp. 255-265. ISSN 0006-3002

Mulligan, G. J., Guo, W., Wormsley, S., Helfman, D. M. (December 1992) Polypyrimidine Tract Binding-Protein Interacts with Sequences Involved in Alternative Splicing of Beta-Tropomyosin Premessenger Rna. Journal of Biological Chemistry, 267 (35). pp. 25480-25487. ISSN 0021-9258

Stamm, S., Casper, D., Dinsmore, J., Kaufmann, C. A., Brosius, J., Helfman, D. M. (October 1992) Clathrin light chain B: gene structure and neuron-specific splicing. Nucleic Acids Res, 20 (19). pp. 5097-103. ISSN 0305-1048 (Print)0305-1048 (Linking)

Lees-Miller, J. P., Helfman, D. M., Schroer, T. A. (September 1992) A vertebrate actin-related protein is a component of a multisubunit complex involved in microtubule-based vesicle motility. Nature, 359 (6392). pp. 244-6. ISSN 0028-0836 (Print)0028-0836 (Linking)

Schroer, T. A., Heuser, J. E., Helfman, D. M., Leesmiller, J. P. (September 1992) Actin-Rpv - the Major Component of the Dynactin Complex - Activator of Cytoplasmic Dynein. Molecular Biology of the Cell, 3. A2-A2. ISSN 1059-1524

Pittenger, M. F., Helfman, D. M. (August 1992) In vitro and in vivo characterization of four fibroblast tropomyosins produced in bacteria: TM-2, TM-3, TM-5a, and TM-5b are co-localized in interphase fibroblasts. J Cell Biol, 118 (4). pp. 841-58. ISSN 0021-9525 (Print)0021-9525 (Linking)

Lees-Miller, J. P., Henry, G., Helfman, D. M. (January 1992) Identification of act2, an essential gene in the fission yeast Schizosaccharomyces pombe that encodes a protein related to actin. Proc Natl Acad Sci U S A, 89 (1). pp. 80-3. ISSN 0027-8424 (Print)0027-8424 (Linking)

Guo, W., Mulligan, G. J., Wormsley, S., Helfman, D. M. (November 1991) Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells. Genes Dev, 5 (11). pp. 2096-107. ISSN 0890-9369 (Print)0890-9369 (Linking)

Helfman, D. M., Guo, W., Lees-Miller, J. P., Mulligan, G. J., Tsukahara, T., Wormsley, S. (October 1991) Alternative Rna Splicing in the Control of Cytoskeletal Protein Gene-Expression. Journal of Muscle Research and Cell Motility, 12 (5). p. 487. ISSN 0142-4319

Lees-Miller, J. P., Helfman, D. M. (September 1991) The molecular basis for tropomyosin isoform diversity. Bioessays, 13 (9). pp. 429-37. ISSN 0265-9247 (Print)0265-9247 (Linking)

Goodwin, L. O., Lees-Miller, J. P., Leonard, M. A., Cheley, S. B., Helfman, D. M. (May 1991) Four fibroblast tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene via alternative RNA splicing and the use of two promoters. J Biol Chem, 266 (13). pp. 8408-15. ISSN 0021-9258 (Print)0021-9258 (Linking)

Helfman, D. M., Guo, W., Mulligan, G. J., Tsukahara, T., Wormsley, S. (1991) Alternative Rna Splicing in the Control of Gene Expression. Journal of Cellular Biochemistry, 47 (Suppl ). p. 15.

Guo, W., Helfman, D. M. (1991) Alternative Rna Splicing of Beta Tropomyosin Pre-Messenger Rna Identification of Exon and Intron Elements That Inhibit the Use of the Skeletal Muscle-Specific Exon in Nonmuscle Cells. Journal of Cellular Biochemistry, 47 (Suppl ). p. 73.

Krainer, A. R., Mayeda, A., Helfman, D., Conway, G. C., Kozak, D. (1991) Biochemistry of Mammalian Nuclear Pre-Messenger Rna Splicing and Splice Site Selection. Journal of Cellular Biochemistry, 47 (Suppl ). p. 45.

Lees-Miller, J. P., Helfman, D. M. (1991) Identification and Analysis of an Essential Gene Encoding a Distinctive Actin-Like Protein from Schizosaccharomyces-Pombe. Journal of Cell Biology, 115 (3 PART). 159A.

Pittenger, M. F., Helfman, D. M. (1991) Localization of Tropomyosin Isoforms in Non-Muscle Cells. Journal of Cell Biology, 115 (3 PART). 378A.

Kazzaz, J. A., Helfman, D. M. (1991) Transcriptional Regulation of the Beta Tropomyosin Gene. Journal of Cellular Biochemistry, 47 (Suppl ). p. 74.

Lees-Miller, J. P., Yan, A., Helfman, D. M. (June 1990) Structure and complete nucleotide sequence of the gene encoding rat fibroblast tropomyosin 4. J Mol Biol, 213 (3). pp. 399-405. ISSN 0022-2836 (Print)0022-2836 (Linking)

Lees-Miller, J. P., Goodwin, L. O., Helfman, D. M. (April 1990) Three novel brain tropomyosin isoforms are expressed from the rat alpha-tropomyosin gene through the use of alternative promoters and alternative RNA processing. Mol Cell Biol, 10 (4). pp. 1729-42. ISSN 0270-7306 (Print)0270-7306 (Linking)

Helfman, D. M., Roscigno, R. F., Mulligan, G. J., Finn, L. A., Weber, K. S. (January 1990) Identification of two distinct intron elements involved in alternative splicing of beta-tropomyosin pre-mRNA. Genes Dev, 4 (1). pp. 98-110. ISSN 0890-9369 (Print)0890-9369 (Linking)

Pittenger, M., Kistler, A., Helfman, D. (1990) The Role of Tropomyosin Diversity in Cellular Function. Journal of Cell Biology, 111 (5 PART). 305A.

Helfman, D. M., Ricci, W. M. (July 1989) Branch point selection in alternative splicing of tropomyosin pre-mRNAs. Nucleic Acids Res, 17 (14). pp. 5633-50. ISSN 0305-1048

Roush, C. L., Kennelly, P. J., Glaccum, M. B., Helfman, D. M., Scott, J. D., Krebs, E. G. (July 1988) Isolation of the Cdna-Encoding Rat Skeletal-Muscle Myosin Light Chain Kinase - Sequence and Tissue Distribution. Journal of Biological Chemistry, 263 (21). pp. 10510-10516. ISSN 0021-9258