Aneuploidy as a promoter and suppressor of malignant growth.

Vasudevan, Anand, Schukken, Klaske M, Sausville, Erin L, Girish, Vishruth, Adebambo, Oluwadamilare A, Sheltzer, Jason M (February 2021) Aneuploidy as a promoter and suppressor of malignant growth. Nature Reviews Cancer, 21 (2). pp. 89-103. ISSN 1474-175X

DOI: 10.1038/s41568-020-00321-1


Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years, but the connection between chromosomal errors and malignant growth has remained obscure. New evidence emerging from both basic and clinical research has illuminated a complicated relationship: despite its frequency in human tumours, aneuploidy is not a universal driver of cancer development and instead can exert substantial tumour-suppressive effects. The specific consequences of aneuploidy are highly context dependent and are influenced by a cell's genetic and environmental milieu. In this Review, we discuss the diverse facets of cancer biology that are shaped by aneuploidy, including metastasis, drug resistance and immune recognition, and we highlight aneuploidy's distinct roles as both a tumour promoter and an anticancer vulnerability.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy
diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:
Communities: CSHL labs > Sheltzer lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: February 2021
Date Deposited: 16 Jun 2021 19:38
Last Modified: 16 Jun 2021 19:39

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