Items where Community is "Sheltzer lab"

Paper

Girish, Vishruth, Lakhani, Asad A, Thompson, Sarah L, Scaduto, Christine M, Brown, Leanne M, Hagenson, Ryan A, Sausville, Erin L, Mendelson, Brianna E, Kandikuppa, Pranav K, Lukow, Devon A, Yuan, Monet Lou, Stevens, Eric C, Lee, Sophia N, Schukken, Klaske M, Akalu, Saron M, Vasudevan, Anand, Zou, Charles, Salovska, Barbora, Li, Wenxue, Smith, Joan C, Taylor, Alison M, Martienssen, Robert A, Liu, Yansheng, Sun, Ruping, Sheltzer, Jason M (August 2023) Oncogene-like addiction to aneuploidy in human cancers. Science, 381 (6660). eadg4521. ISSN 0036-8075 (Public Dataset)

Girish, Vishruth, Lakhani, Asad A, Scaduto, Christine M, Thompson, Sarah L, Brown, Leanne M, Hagenson, Ryan A, Sausville, Erin L, Mendelson, Brianna E, Lukow, Devon A, Yuan, Monet Lou, Kandikuppa, Pranav K, Stevens, Eric C, Lee, Sophia N, Salovska, Barbora, Li, Wenxue, Smith, Joan C, Taylor, Alison M, Martienssen, Robert A, Liu, Yansheng, Sun, Ruping, Sheltzer, Jason M (January 2023) Oncogene-like addiction to aneuploidy in human cancers. bioRxiv. (Public Dataset) (Submitted)

Li, Zhengnian, Ishida, Ryosuke, Liu, Yan, Wang, Jinhua, Li, Yina, Gao, Yang, Jiang, Jie, Che, Jianwei, Sheltzer, Jason M, Robers, Matthew B, Zhang, Tinghu, Westover, Kenneth D, Nabet, Behnam, Gray, Nathanael S (May 2022) Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold. European Journal of Medicinal Chemistry, 238. p. 114433. ISSN 0223-5234

Smith, Joan C, Sheltzer, Jason M (March 2022) Genome-wide identification and analysis of prognostic features in human cancers. Cell Reports, 38 (13). p. 110569. ISSN 2211-1247

Chen, Wei-Chia, Zhou, Juannan, Sheltzer, Jason M, Kinney, Justin B, McCandlish, David M (October 2021) Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer. Proceedings of the National Academy of Sciences of USA, 118 (40). ISSN 1091-6490

Lukow, Devon A, Sheltzer, Jason M (September 2021) Chromosomal instability and aneuploidy as causes of cancer drug resistance. Trends in Cancer. ISSN 2405-8033

Lukow, Devon A, Sausville, Erin L, Suri, Pavit, Chunduri, Narendra Kumar, Wieland, Angela, Leu, Justin, Smith, Joan C, Girish, Vishruth, Kumar, Ankith A, Kendall, Jude, Wang, Zihua, Storchova, Zuzana, Sheltzer, Jason M (August 2021) Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. Developmental Cell. ISSN 1534-5807

Hoffmann, Markus, Hofmann-Winkler, Heike, Smith, Joan C, Krüger, Nadine, Arora, Prerna, Sørensen, Lambert K, Søgaard, Ole S, Hasselstrøm, Jørgen Bo, Winkler, Michael, Hempel, Tim, Raich, Lluís, Olsson, Simon, Danov, Olga, Jonigk, Danny, Yamazoe, Takashi, Yamatsuta, Katsura, Mizuno, Hirotaka, Ludwig, Stephan, Noé, Frank, Kjolby, Mads, Braun, Armin, Sheltzer, Jason M, Pöhlmann, Stefan (March 2021) Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine, 65. p. 103255. ISSN 2352-3964

Vasudevan, Anand, Schukken, Klaske M, Sausville, Erin L, Girish, Vishruth, Adebambo, Oluwadamilare A, Sheltzer, Jason M (February 2021) Aneuploidy as a promoter and suppressor of malignant growth. Nature Reviews Cancer, 21 (2). pp. 89-103. ISSN 1474-175X

Sheltzer, J. M., Visintin, R. (December 2020) Angelika Amon (1967-2020). Science, 370 (6522). p. 1276. ISSN 0036-8075

Chen, Wei-Chia, Zhou, Juannan, Sheltzer, Jason, Kinney, Justin, McCandlish, David (December 2020) Non-parametric Bayesian density estimation for biological sequence space with applications to pre-mRNA splicing and the karyotypic diversity of human cancer. BioRxiv. (Unpublished)

Replogle, J. M., Zhou, W., Amaro, A. E., McFarland, J. M., Villalobos-Ortiz, M., Ryan, J., Letai, A., Yilmaz, O., Sheltzer, J., Lippard, S. J., Ben-David, U., Amon, A. (December 2020) Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division. Proc Natl Acad Sci U S A, 117 (48). pp. 30566-30576. ISSN 0027-8424 (Print)0027-8424

Girish, Vishruth, Sheltzer, Jason M (July 2020) A CRISPR Competition Assay to Identify Cancer Genetic Dependencies. Bio-protocol, 10 (14). e3682. ISSN 2331-8325

Lin, A., Sheltzer, J.M. (June 2020) Discovering and Validating Cancer Genetic Dependencies: Approaches and Pitfalls. Nat Rev Genet. ISSN 1471-0056

Smith, J.C., Sausville, E. L., Girish, V., Yuan, M.L., Vasudevan, A., John, K.M., Sheltzer, J. M. (May 2020) Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. Dev Cell, 53 (5). 514-529.e3. ISSN 1534-5807

Vasudevan, A., Baruah, P.S., Smith, J.C., Wang, Z., Sayles, N. M., Andrews, P., Kendall, J., Leu, J., Chunduri, N.K., Levy, D., Wigler, M., Storchova, Z., Sheltzer, J. M. (February 2020) Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell, 52 (4). pp. 413-428. ISSN 1534-5807

Kneissig, M., Keuper, K., de Pagter, M. S., van Roosmalen, M. J., Martin, J., Otto, H., Passerini, V., Campos Sparr, A., Renkens, I., Kropveld, F., Vasudevan, A., Sheltzer, J. M., Kloosterman, W. P., Storchova, Z. (November 2019) Micronuclei-based model system reveals functional consequences of chromothripsis in human cells. Elife, 8. e50292. ISSN 2050-084x (Public Dataset)

Greider, Carol W, Sheltzer, Jason M, Cantalupo, Nancy C, Copeland, Wilbert B, Dasgupta, Nilanjana, Hopkins, Nancy, Jansen, Jaclyn M, Joshua-Tor, Leemor, McDowell, Gary S, Metcalf, Jessica L, McLaughlin, BethAnn, Olivarius, Ann, O'Shea, Erin K, Raymond, Jennifer L, Ruebain, David, Steitz, Joan A, Stillman, Bruce, Tilghman, Shirley M, Valian, Virginia, Villa-Komaroff, Lydia, Wong, Joyce Y (November 2019) Increasing gender diversity in the STEM research workforce. Science, 366 (6466). pp. 692-695. ISSN 0036-8075

Lin, A., Giuliano, C. J., Palladino, A., John, K. M., Abramowicz, C., Yuan, M. L., Sausville, E. L., Lukow, D. A., Liu, L., Chait, A. R., Galluzzo, Z. C., Tucker, C., Sheltzer, J. M. (September 2019) Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. Sci Transl Med, 11 (509). ISSN 1946-6234

Giuliano, C. J., Lin, A., Girish, V., Sheltzer, J. M. (September 2019) Generating Single Cell-Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9. Curr Protoc Mol Biol, 128 (1). e100. ISSN 1934-3639 (Print)1934-3647

Giuliano, C. J., Lin, A., Girish, V., Sheltzer, J. M. (August 2019) Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9. Current Protocols in Molecular Biology, 128 (1). Art number e100. ISSN 19343639 (ISSN)

Smith, J. C., Sheltzer, J. M. (December 2018) Systematic identification of mutations and copy number alterations associated with cancer patient prognosis. Elife, 7. ISSN 2050-084x

Sheltzer, J. M. (October 2018) Gender disparities among independent fellows in biomedical research. Nat Biotechnol, 36 (10). pp. 1018-1021. ISSN 1087-0156

Giuliano, C. J., Lin, A., Smith, J. C., Palladino, A. C., Sheltzer, J. M. (July 2018) Combining CRISPR/Cas9 mutagenesis and a small-molecule inhibitor to probe the function of MELK in cancer. Cancer Research, 78 (13 S). Meeting Abstract: 837A . ISSN 0008-5472

Giuliano, C. J., Lin, A., Smith, J. C., Palladino, A. C., Sheltzer, J. M. (February 2018) MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Elife, 7. ISSN 2050-084x

Scaduto, C. M., Kabrawala, S., Thomson, G. J., Scheving, W., Ly, A., Anderson, M. Z., Whiteway, M., Bennett, R. J. (December 2017) Epigenetic control of pheromone MAPK signaling determines sexual fecundity in Candida albicans. Proc Natl Acad Sci U S A, 114 (52). pp. 13780-13785. ISSN 0027-8424

Lin, A., Giuliano, C. J., Sayles, N. M., Sheltzer, J. M. (March 2017) CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials. Elife, 6. e24179. ISSN 2050-084x

Sheltzer, Jason M., Ko, Julie H., Replogle, John M., Habibe Burgos, Nicole C., Chung, Erica S., Meehl, Colleen M., Sayles, Nicole M., Passerini, Verena, Storchova, Zuzana, Amon, Angelika (February 2017) Single-chromosome Gains Commonly Function as Tumor Suppressors. Cancer Cell, 31 (2). pp. 240-255. ISSN 1535-6108 (Public Dataset)

Sheltzer, J. (December 2016) Single-chromosome aneuploidy commonly functions as a tumor suppressor. Molecular Biology of the Cell, 27. A10. ISSN 1059-1524

Dodgson, S. E., Santaguida, S., Kim, S., Sheltzer, J., Amon, A. (November 2016) The pleiotropic deubiquitinase Ubp3 confers aneuploidy tolerance. Genes Dev. ISSN 1549-5477 (Electronic)0890-9369 (Linking)

Blank, H. M., Sheltzer, J. M., Meehl, C. M., Amon, A. (April 2015) Mitotic entry in the presence of DNA damage is a widespread property of aneuploidy in yeast. Mol Biol Cell, 26 (8). pp. 1440-51. ISSN 1939-4586 (Electronic)1059-1524 (Linking)

McGregor, J (July 2014) Study: Top labs run by men tend to hire fewer women. Washington Post.

Sheltzer, J. M., Smith, J. C. (July 2014) Elite male faculty in the life sciences employ fewer women. Proc Natl Acad Sci U S A, 111 (28). pp. 10107-12. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Sheltzer, J. M. (November 2013) A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis. Cancer Res, 73 (21). pp. 6401-12. ISSN 1538-7445 (Electronic)0008-5472 (Linking)

Sheltzer, J. M., Torres, E. M., Dunham, M. J., Amon, A. (July 2012) Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A, 109 (31). pp. 12644-9. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

Sheltzer, J. M., Amon, A. (November 2011) The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet, 27 (11). pp. 446-53. ISSN 0168-9525 (Print)0168-9525 (Linking)

Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., Brito, I. L., Hiraoka, Y., Niwa, O., Amon, A. (August 2011) Aneuploidy drives genomic instability in yeast. Science, 333 (6045). pp. 1026-30. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

Akst, J. (August 2011) Chromosomes and Cancer. The Scientist.

Sheltzer, J. M., Rose, M. D. (June 2009) The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response. Mol Biol Cell, 20 (12). pp. 2909-19. ISSN 1939-4586 (Electronic)1059-1524 (Linking)

Thesis

Lakhani, Asad A (March 2023) The Role of Recurrently Observed Aneuploidy in Tumorigenesis. PhD thesis, Cold Spring Harbor Laboratory.