Aneuploidy as a promoter and suppressor of malignant growth

Vasudevan, Anand, Schukken, Klaske M, Sausville, Erin L, Girish, Vishruth, Adebambo, Oluwadamilare A, Sheltzer, Jason M (February 2021) Aneuploidy as a promoter and suppressor of malignant growth. Nature Reviews Cancer, 21 (2). pp. 89-103. ISSN 1474-175X

URL: https://www.ncbi.nlm.nih.gov/pubmed/33432169

DOI: 10.1038/s41568-020-00321-1

Abstract

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years, but the connection between chromosomal errors and malignant growth has remained obscure. New evidence emerging from both basic and clinical research has illuminated a complicated relationship: despite its frequency in human tumours, aneuploidy is not a universal driver of cancer development and instead can exert substantial tumour-suppressive effects. The specific consequences of aneuploidy are highly context dependent and are influenced by a cell's genetic and environmental milieu. In this Review, we discuss the diverse facets of cancer biology that are shaped by aneuploidy, including metastasis, drug resistance and immune recognition, and we highlight aneuploidy's distinct roles as both a tumour promoter and an anticancer vulnerability.

Item Type:	Paper
Subjects:	bioinformatics diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders diseases & disorders > mental disorders > genetic disorders > Down syndrome bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > mental disorders diseases & disorders > neoplasms bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy organism description > animal organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell transformation organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications diseases & disorders > mental disorders > genetic disorders organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions organism description > animal > mammal > rodent diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:	Vasudevan, Anand Sausville, Erin L Girish, Vishruth Sheltzer, Jason
Communities:	CSHL labs > Sheltzer lab CSHL Cancer Center Program CSHL Cancer Center Program > Gene Regulation and Inheritance Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	February 2021
Date Deposited:	16 Jun 2021 19:38
Last Modified:	13 Feb 2024 19:29
URI:	https://repository.cshl.edu/id/eprint/40217

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