Diversity and Biology of Cancer-Associated Fibroblasts.

Biffi, Giulia, Tuveson, David A (January 2021) Diversity and Biology of Cancer-Associated Fibroblasts. Physiological Reviews, 101 (1). pp. 147-176. ISSN 0031-9333

URL: https://www.ncbi.nlm.nih.gov/pubmed/32466724
DOI: 10.1152/physrev.00048.2019

Abstract

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the progression of the tumor. Indeed, cancer cell survival, growth, migration, and even dormancy are influenced by the surrounding tumor microenvironment (TME). Within the TME, cancer-associated fibroblasts (CAFs) have been shown to play several roles in the development of a tumor. They secrete growth factors, inflammatory ligands, and extracellular matrix proteins that promote cancer cell proliferation, therapy resistance, and immune exclusion. However, recent work indicates that CAFs may also restrain tumor progression in some circumstances. In this review, we summarize the body of work on CAFs, with a particular focus on the most recent discoveries about fibroblast heterogeneity, plasticity, and functions. We also highlight the commonalities of fibroblasts present across different cancer types, and in normal and inflammatory states. Finally, we present the latest advances regarding therapeutic strategies targeting CAFs that are undergoing preclinical and clinical evaluation.

Item Type: Paper
Subjects: diseases & disorders > cancer > drugs and therapies
Publication Type > review
diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:
Communities: CSHL labs > Tuveson lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 1 January 2021
Date Deposited: 06 May 2021 19:01
Last Modified: 06 May 2021 19:01
PMCID: PMC7864232
Related URLs:
URI: https://repository.cshl.edu/id/eprint/40027

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