Diversity and Biology of Cancer-Associated Fibroblasts.

Biffi, Giulia, Tuveson, David A (January 2021) Diversity and Biology of Cancer-Associated Fibroblasts. Physiological Reviews, 101 (1). pp. 147-176. ISSN 0031-9333

URL: https://www.ncbi.nlm.nih.gov/pubmed/32466724

DOI: 10.1152/physrev.00048.2019

Abstract

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the progression of the tumor. Indeed, cancer cell survival, growth, migration, and even dormancy are influenced by the surrounding tumor microenvironment (TME). Within the TME, cancer-associated fibroblasts (CAFs) have been shown to play several roles in the development of a tumor. They secrete growth factors, inflammatory ligands, and extracellular matrix proteins that promote cancer cell proliferation, therapy resistance, and immune exclusion. However, recent work indicates that CAFs may also restrain tumor progression in some circumstances. In this review, we summarize the body of work on CAFs, with a particular focus on the most recent discoveries about fibroblast heterogeneity, plasticity, and functions. We also highlight the commonalities of fibroblasts present across different cancer types, and in normal and inflammatory states. Finally, we present the latest advances regarding therapeutic strategies targeting CAFs that are undergoing preclinical and clinical evaluation.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders diseases & disorders > neoplasms diseases & disorders > cancer > cancer-associated cell types diseases & disorders > cancer > cancer-associated cell types > cancer-associated fibroblast organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions diseases & disorders > cancer > drugs and therapies organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions Publication Type > review diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:	Biffi, Giulia Tuveson, David A.
Communities:	CSHL labs > Tuveson lab CSHL Cancer Center Program CSHL Cancer Center Program > Cellular Communication in Cancer Program
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	1 January 2021
Date Deposited:	06 May 2021 19:01
Last Modified:	09 Feb 2024 21:08
PMCID:	PMC7864232
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40027

Actions (login required)

Administrator's edit/view item