Evolution of buffering in a genetic circuit controlling plant stem cell proliferation

Rodriguez-Leal, D., Xu, C., Kwon, C. T., Soyars, C., Demesa-Arevalo, E., Man, J., Liu, L., Lemmon, Z. H., Jones, D. S., Van Eck, J., Jackson, D. P., Bartlett, M. E., Nimchuk, Z. L., Lippman, Z. B. (April 2019) Evolution of buffering in a genetic circuit controlling plant stem cell proliferation. Nat Genet, 51 (5). pp. 786-792. ISSN 1061-4036

Abstract

Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs(1,2). The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit(1,2). In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation(3). Here, we show that compensation(4,5) operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs.

Item Type:	Paper
Subjects:	organism description > plant > Arabidopsis bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > plant > maize organs, tissues, organelles, cell types and functions > cell types and functions > cell functions organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > genomics and proteomics > small molecules > cofactors evolution bioinformatics > genomics and proteomics > small molecules > cofactors > ligands organs, tissues, organelles, cell types and functions > tissues types and functions > meristem bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations organs, tissues, organelles, cell types and functions organism description > plant organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction bioinformatics > genomics and proteomics > small molecules organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > tissues types and functions organism description > plant > tomato
CSHL Authors:	Jackson, David P. Lippman, Zachary B. Rodriguez-Leal, Daniel Xu, Cao Kwon, Choon-Tak Demesa Arevalo, Edgar Liu, Lei Lemmon, Zachary
Communities:	CSHL labs > Jackson lab CSHL labs > Lippman lab
Depositing User:	Matthew Dunn
Date:	15 April 2019
Date Deposited:	22 May 2019 14:39
Last Modified:	02 Feb 2024 20:25
PMCID:	PMC7274162
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/37838

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