Rodriguez-Leal, D., Xu, C., Kwon, C. T., Soyars, C., Demesa-Arevalo, E., Man, J., Liu, L., Lemmon, Z. H., Jones, D. S., Van Eck, J., Jackson, D. P., Bartlett, M. E., Nimchuk, Z. L., Lippman, Z. B.
(April 2019)
Evolution of buffering in a genetic circuit controlling plant stem cell proliferation.
Nat Genet, 51 (5).
pp. 786-792.
ISSN 1061-4036
Abstract
Precise control of plant stem cell proliferation is necessary for the continuous and reproducible development of plant organs(1,2). The peptide ligand CLAVATA3 (CLV3) and its receptor protein kinase CLAVATA1 (CLV1) maintain stem cell homeostasis within a deeply conserved negative feedback circuit(1,2). In Arabidopsis, CLV1 paralogs also contribute to homeostasis, by compensating for the loss of CLV1 through transcriptional upregulation(3). Here, we show that compensation(4,5) operates in diverse lineages for both ligands and receptors, but while the core CLV signaling module is conserved, compensation mechanisms have diversified. Transcriptional compensation between ligand paralogs operates in tomato, facilitated by an ancient gene duplication that impacted the domestication of fruit size. In contrast, we found little evidence for transcriptional compensation between ligands in Arabidopsis and maize, and receptor compensation differs between tomato and Arabidopsis. Our findings show that compensation among ligand and receptor paralogs is critical for stem cell homeostasis, but that diverse genetic mechanisms buffer conserved developmental programs.
| Item Type: |
Paper
|
| Subjects: |
organism description > plant > Arabidopsis
bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
organism description > plant > maize
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell proliferation
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell signaling
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions
bioinformatics > genomics and proteomics > small molecules > cofactors
evolution
bioinformatics > genomics and proteomics > small molecules > cofactors > ligands
organs, tissues, organelles, cell types and functions > tissues types and functions > meristem
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations
organs, tissues, organelles, cell types and functions
organism description > plant
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
bioinformatics > genomics and proteomics > small molecules
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > tissues types and functions
organism description > plant > tomato |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Jackson lab
CSHL labs > Lippman lab |
| Depositing User: |
Matthew Dunn
|
| Date: |
15 April 2019 |
| Date Deposited: |
22 May 2019 14:39 |
| Last Modified: |
02 Feb 2024 20:25 |
| PMCID: |
PMC7274162 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/37838 |
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