Combination therapy to checkmate Glioblastoma: clinical challenges and advances

Ghosh, D., Nandi, S., Bhattacharjee, S. (October 2018) Combination therapy to checkmate Glioblastoma: clinical challenges and advances. Clin Transl Med, 7 (1). p. 33. ISSN 2001-1326 (Print)

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Abstract

Combination therapy is increasingly becoming the cornerstone of current day antitumor therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival post diagnosis and a high rate of disease recurrence. The poor prognosis can be attributed to unique treatment limitations, which include the infiltrative nature of tumor cells, failure of anti-glioma drugs to cross the blood-brain barrier, tumor heterogeneity and the highly metastatic and angiogenic nature of the tumor making cells resistant to chemotherapy. Combination therapy approach is being developed against glioblastoma with new innovative combination drug regimens being tested in preclinical and clinical trials. In this review, we discuss the pathophysiology of glioblastoma, diagnostic markers, therapeutic targeting strategies, current treatment limitations, novel combination therapies in the context of current treatment options and the ongoing clinical trials for glioblastoma therapy.

Item Type:	Paper
Subjects:	diseases & disorders > cancer diseases & disorders organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions diseases & disorders > cancer > drugs and therapies > chemotherapy diseases & disorders > cancer > drugs and therapies diseases & disorders > cancer > cancer types > glioblastoma diseases & disorders > cancer > drugs and therapies > Immunotherapy organs, tissues, organelles, cell types and functions diseases & disorders > cancer > drugs and therapies > precision medicine organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells diseases & disorders > cancer > cancer types
CSHL Authors:	Bhattacharjee, Sonali Nandi, Saikat Ghosh, Debarati
Communities:	CSHL labs > Lee lab CSHL labs > Martienssen lab CSHL labs > Stillman lab
Depositing User:	Matthew Dunn
Date:	16 October 2018
Date Deposited:	01 Nov 2018 18:34
Last Modified:	20 Feb 2024 19:40
PMCID:	PMC6191404
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/37285

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