Ghosh, D., Nandi, S., Bhattacharjee, S.
(October 2018)
Combination therapy to checkmate Glioblastoma: clinical challenges and advances.
Clin Transl Med, 7 (1).
p. 33.
ISSN 2001-1326 (Print)
Abstract
Combination therapy is increasingly becoming the cornerstone of current day antitumor therapy. Glioblastoma multiforme is an aggressive brain tumor with a dismal median survival post diagnosis and a high rate of disease recurrence. The poor prognosis can be attributed to unique treatment limitations, which include the infiltrative nature of tumor cells, failure of anti-glioma drugs to cross the blood-brain barrier, tumor heterogeneity and the highly metastatic and angiogenic nature of the tumor making cells resistant to chemotherapy. Combination therapy approach is being developed against glioblastoma with new innovative combination drug regimens being tested in preclinical and clinical trials. In this review, we discuss the pathophysiology of glioblastoma, diagnostic markers, therapeutic targeting strategies, current treatment limitations, novel combination therapies in the context of current treatment options and the ongoing clinical trials for glioblastoma therapy.
| Item Type: |
Paper
|
| Subjects: |
diseases & disorders > cancer
diseases & disorders
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions > cell types
organs, tissues, organelles, cell types and functions > cell types and functions
diseases & disorders > cancer > drugs and therapies > chemotherapy
diseases & disorders > cancer > drugs and therapies
diseases & disorders > cancer > cancer types > glioblastoma
diseases & disorders > cancer > drugs and therapies > Immunotherapy
organs, tissues, organelles, cell types and functions
diseases & disorders > cancer > drugs and therapies > precision medicine
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > stem cells
diseases & disorders > cancer > cancer types |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Lee lab
CSHL labs > Martienssen lab
CSHL labs > Stillman lab
CSHL Post Doctoral Fellows |
| Depositing User: |
Matthew Dunn
|
| Date: |
16 October 2018 |
| Date Deposited: |
01 Nov 2018 18:34 |
| Last Modified: |
18 Nov 2025 20:44 |
| PMCID: |
PMC6191404 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/37285 |
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