Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., Parsons, R. (March 1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275 (5308). pp. 1943-7. ISSN 0036-8075 (Print)
Abstract
Mapping of homozygous deletions on human chromosome 10q23 has led to the isolation of a candidate tumor suppressor gene, PTEN, that appears to be mutated at considerable frequency in human cancers. In preliminary screens, mutations of PTEN were detected in 31% (13/42) of glioblastoma cell lines and xenografts, 100% (4/4) of prostate cancer cell lines, 6% (4/65) of breast cancer cell lines and xenografts, and 17% (3/18) of primary glioblastomas. The predicted PTEN product has a protein tyrosine phosphatase domain and extensive homology to tensin, a protein that interacts with actin filaments at focal adhesions. These homologies suggest that PTEN may suppress tumor cell growth by antagonizing protein tyrosine kinases and may regulate tumor cell invasion and metastasis through interactions at focal adhesions.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Amino Acid Sequence Brain Neoplasms genetics Breast Neoplasms genetics Chromosome Mapping Chromosomes Human Pair 10 Female Frameshift Mutation Genes, Tumor Suppressor Glioblastoma genetics Humans Male Microfilament Proteins chemistry Molecular Sequence Data Mutation Neoplasm Transplantation Neoplasms genetics PTEN Phosphohydrolase Phosphoric Monoester Hydrolases Phosphotyrosine metabolism Prostatic Neoplasms genetics Protein-Tyrosine Kinases antagonists & inhibitors Protein-Tyrosine-Phosphatase chemistry genetics physiology Sequence Deletion Sequence Homology Amino Acid Transplantation Heterologous Tumor Cells Cultured Tumor Suppressor Proteins |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > PTEN bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase > tyrosine kinase bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase |
| CSHL Authors: | |
| Communities: | CSHL labs > McCombie lab CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | 28 March 1997 |
| Date Deposited: | 12 Apr 2012 14:00 |
| Last Modified: | 11 Apr 2013 20:34 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26217 |
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