Daar, I., Nebreda, A. R., Yew, N., Sass, P., Paules, R., Santos, E., Wigler, M. H., Vandewoude, G. F.
(July 1991)
The Ras Oncoprotein and M-Phase Activity.
Science, 253 (5015).
pp. 74-76.
ISSN 0036-8075
Abstract
The endogenous mos proto-oncogene product (Mos) is required for meiotic maturation In Xenopus oocytes, the ras oncogene product (Ras) can induce meiotic maturation and high levels of M-phase-promoting factor (MPF) independent of endogenous Mos, indicating that a parallel pathway to metaphase exists. In addition, Ras, like Mos and cytostatic factor, can arrest Xenopus embryonic cell cleavage in mitosis and maintain high levels of MPF. Thus, in the Xenopus oocyte and embryo systems Ras functions in the M phase of the cell cycle. The embryonic cleavage arrest assay is a rapid and sensitive test for Ras function.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
MOS PROTO-ONCOGENE
MOS proto-oncogene
MATURATION-PROMOTING FACTOR
maturation promoting factor
MURINE SARCOMA-VIRUS
murine sarcoma virus
XENOPUS OOCYTES
Xenopus oocytes
CELL-CYCLE
cell cycle
MEIOTIC MATURATION
meitotic maturation
GENE-PRODUCT
gene product
ARREST
arrest
P21
p21
EGGS
eggs |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
organism description > animal > developmental stage > embryo
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein characterization
organism description > animal > Frog > xenopus |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Wigler lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
July 1991 |
| Date Deposited: |
19 Apr 2012 14:38 |
| Last Modified: |
18 Nov 2016 17:21 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/26174 |
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