Building up the tension between the epithelial and stromal compartment in pancreatic ductal adenocarcinoma

Biffi, G., Ohlund, D., Tuveson, D. (2016) Building up the tension between the epithelial and stromal compartment in pancreatic ductal adenocarcinoma. Cell Death Differ, 23 (8). pp. 1265-1266. ISSN 1476-5403 (Electronic)1350-9047 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/27285108
DOI: 10.1038/cdd.2016.50

Abstract

In recent years, pancreatic cancer-associated stroma has been the topic of a number of studies that have proposed stromal components as promising, but still controversial, targets for novel therapeutic strategies. A new study describes how epithelial TGF-β signalling deficiency and consequential STAT3 activation act as key players in modulating the desmoplastic reaction, with implications for both clinical outcome and future drug development

Item Type: Paper
Subjects: diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:
Communities: CSHL labs > Tuveson lab
Depositing User: Matt Covey
Date Deposited: 23 Jun 2016 14:24
Last Modified: 04 Aug 2016 20:08
PMCID: PMC4947673
Related URLs:
URI: http://repository.cshl.edu/id/eprint/32881

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