Biffi, G., Ohlund, D., Tuveson, D. (August 2016) Building up the tension between the epithelial and stromal compartment in pancreatic ductal adenocarcinoma. Cell Death Differ, 23 (8). pp. 1265-1266. ISSN 1476-5403 (Electronic)1350-9047 (Linking)
DOI: 10.1038/cdd.2016.50
Abstract
In recent years, pancreatic cancer-associated stroma has been the topic of a number of studies that have proposed stromal components as promising, but still controversial, targets for novel therapeutic strategies. A new study describes how epithelial TGF-β signalling deficiency and consequential STAT3 activation act as key players in modulating the desmoplastic reaction, with implications for both clinical outcome and future drug development
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer > cancer types > pancreatic cancer |
| CSHL Authors: | |
| Communities: | CSHL labs > Tuveson lab |
| Depositing User: | Matt Covey |
| Date: | 10 August 2016 |
| Date Deposited: | 23 Jun 2016 14:24 |
| Last Modified: | 04 Aug 2016 20:08 |
| PMCID: | PMC4947673 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32881 |
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