A Biochemical Phenotype for a Disease Resistance Gene of Maize

Meeley, R. B., Johal, G. S., Briggs, S. P., Walton, J. D. (January 1992) A Biochemical Phenotype for a Disease Resistance Gene of Maize. Plant Cell, 4 (1). pp. 71-77. ISSN 1532-298X (Electronic)1040-4651 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/12297630
DOI: 10.1105/tpc.4.1.71

Abstract

In maize, major resistance to the pathogenic fungus Cochliobolus (Helminthosporium) carbonum race 1 is determined by the dominant allele of the nuclear locus hm. The interaction between C. carbonum race 1 and maize is mediated by a pathogen-produced, low molecular weight compound called HC-toxin. We recently described an enzyme from maize, called HC-toxin reductase, that inactivates HC-toxin by pyridine nucleotide-dependent reduction of an essential carbonyl group. We now report that this enzyme activity is detectable only in extracts of maize that are resistant to C. carbonum race 1 (genotype Hm/Hm or Hm/hm). In several genetic analyses, in vitro HC-toxin reductase activity was without exception associated with resistance to C. carbonum race 1. The results indicate that detoxification of HC-toxin is the biochemical basis of Hm-specific resistance of maize to infection by C. carbonum race 1.

Item Type: Paper
Uncontrolled Keywords: HOST-SPECIFIC TOXIN HELMINTHOSPORIUM-CARBONUM HC-TOXIN
Subjects: diseases & disorders
organism description > plant > maize
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: January 1992
Date Deposited: 22 Sep 2015 14:50
Last Modified: 22 Sep 2015 14:50
PMCID: PMC160107
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31850

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