Meeley, R. B., Johal, G. S., Briggs, S. P., Walton, J. D. (January 1992) A Biochemical Phenotype for a Disease Resistance Gene of Maize. Plant Cell, 4 (1). pp. 71-77. ISSN 1532-298X (Electronic)1040-4651 (Linking)
Abstract
In maize, major resistance to the pathogenic fungus Cochliobolus (Helminthosporium) carbonum race 1 is determined by the dominant allele of the nuclear locus hm. The interaction between C. carbonum race 1 and maize is mediated by a pathogen-produced, low molecular weight compound called HC-toxin. We recently described an enzyme from maize, called HC-toxin reductase, that inactivates HC-toxin by pyridine nucleotide-dependent reduction of an essential carbonyl group. We now report that this enzyme activity is detectable only in extracts of maize that are resistant to C. carbonum race 1 (genotype Hm/Hm or Hm/hm). In several genetic analyses, in vitro HC-toxin reductase activity was without exception associated with resistance to C. carbonum race 1. The results indicate that detoxification of HC-toxin is the biochemical basis of Hm-specific resistance of maize to infection by C. carbonum race 1.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | HOST-SPECIFIC TOXIN HELMINTHOSPORIUM-CARBONUM HC-TOXIN |
| Subjects: | diseases & disorders organism description > plant > maize bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | January 1992 |
| Date Deposited: | 22 Sep 2015 14:50 |
| Last Modified: | 22 Sep 2015 14:50 |
| PMCID: | PMC160107 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/31850 |
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