Aneuploidy drives genomic instability in yeast

Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., Brito, I. L., Hiraoka, Y., Niwa, O., Amon, A. (2011) Aneuploidy drives genomic instability in yeast. Science, 333 (6045). pp. 1026-30. ISSN 1095-9203 (Electronic)0036-8075 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/21852501
DOI: 10.1126/science.1206412

Abstract

Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.

Item Type: Paper
Uncontrolled Keywords: *Aneuploidy Chromosome Segregation Chromosomes, Fungal/genetics *DNA Damage *DNA Repair DNA Replication DNA, Fungal/genetics/metabolism *Genome, Fungal *Genomic Instability Mutagenesis Mutation Neoplasms/genetics Phenotype Rad52 DNA Repair and Recombination Protein/genetics *Recombination, Genetic Saccharomyces cerevisiae/*genetics Saccharomyces cerevisiae Proteins/genetics
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome

bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations > mutagenesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > recombination
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Sheltzer lab
Depositing User: Matt Covey
Date Deposited: 10 Sep 2015 18:55
Last Modified: 10 Sep 2015 18:55
PMCID: PMC3278960
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31748

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