Sheltzer, J. M., Blank, H. M., Pfau, S. J., Tange, Y., George, B. M., Humpton, T. J., Brito, I. L., Hiraoka, Y., Niwa, O., Amon, A.
(August 2011)
Aneuploidy drives genomic instability in yeast.
Science, 333 (6045).
pp. 1026-30.
ISSN 1095-9203 (Electronic)0036-8075 (Linking)
Abstract
Aneuploidy decreases cellular fitness, yet it is also associated with cancer, a disease of enhanced proliferative capacity. To investigate one mechanism by which aneuploidy could contribute to tumorigenesis, we examined the effects of aneuploidy on genomic stability. We analyzed 13 budding yeast strains that carry extra copies of single chromosomes and found that all aneuploid strains exhibited one or more forms of genomic instability. Most strains displayed increased chromosome loss and mitotic recombination, as well as defective DNA damage repair. Aneuploid fission yeast strains also exhibited defects in mitotic recombination. Aneuploidy-induced genomic instability could facilitate the development of genetic alterations that drive malignant growth in cancer.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
*Aneuploidy
Chromosome Segregation
Chromosomes, Fungal/genetics
*DNA Damage
*DNA Repair
DNA Replication
DNA, Fungal/genetics/metabolism
*Genome, Fungal
*Genomic Instability
Mutagenesis
Mutation
Neoplasms/genetics
Phenotype
Rad52 DNA Repair and Recombination Protein/genetics
*Recombination, Genetic
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/genetics |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > DNA replication
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations > mutagenesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > recombination
organism description > yeast |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Sheltzer lab |
| Depositing User: |
Matt Covey
|
| Date: |
19 August 2011 |
| Date Deposited: |
10 Sep 2015 18:55 |
| Last Modified: |
02 Oct 2019 15:25 |
| PMCID: |
PMC3278960 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/31748 |
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