Transcriptional consequences of aneuploidy

Sheltzer, J. M., Torres, E. M., Dunham, M. J., Amon, A. (2012) Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A, 109 (31). pp. 12644-9. ISSN 1091-6490 (Electronic)0027-8424 (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/22802626
DOI: 10.1073/pnas.1209227109

Abstract

Aneuploidy, or an aberrant karyotype, results in developmental disabilities and has been implicated in tumorigenesis. However, the causes of aneuploidy-induced phenotypes and the consequences of aneuploidy on cell physiology remain poorly understood. We have performed a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, plants, mice, and humans. We found highly related gene expression patterns that are conserved between species: genes that were involved in the response to stress were consistently upregulated, and genes associated with the cell cycle and cell proliferation were downregulated in aneuploid cells. Within species, different aneuploidies induced similar changes in gene expression, independent of the specific chromosomal aberrations. Taken together, our results demonstrate that aneuploidies of different chromosomes and in different organisms impact similar cellular pathways and cause a stereotypical antiproliferative response that must be overcome before transformation.

Item Type: Paper
Uncontrolled Keywords: *Aneuploidy Animals Arabidopsis/genetics/*metabolism Cell Line Gene Expression Regulation, Fungal/*physiology Gene Expression Regulation, Plant/*physiology Humans Mice Saccharomyces cerevisiae/genetics/*metabolism Schizosaccharomyces/genetics/*metabolism Species Specificity Transcription, Genetic/*physiology
Subjects: organism description > plant > Arabidopsis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomal duplications > aneuploidy
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Sheltzer lab
Depositing User: Matt Covey
Date Deposited: 10 Sep 2015 18:46
Last Modified: 10 Sep 2015 18:46
PMCID: PMC3411958
Related URLs:
URI: http://repository.cshl.edu/id/eprint/31747

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving