Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes

Li, Wanhe, Mills, Alea A. (August 2014) Architects of the genome: CHD dysfunction in cancer, developmental disorders and neurological syndromes. Epigenomics, 6 (4). pp. 381-95. ISSN 1750-192x

URL: http://www.ncbi.nlm.nih.gov/pubmed/25333848
DOI: 10.2217/epi.14.31

Abstract

Chromatin is vital to normal cells, and its deregulation contributes to a spectrum of human ailments. An emerging concept is that aberrant chromatin regulation culminates in gene expression programs that set the stage for the seemingly diverse pathologies of cancer, developmental disorders and neurological syndromes. However, the mechanisms responsible for such common etiology have been elusive. Recent evidence has implicated lesions affecting chromatin-remodeling proteins in cancer, developmental disorders and neurological syndromes, suggesting a common source for these different pathologies. Here, we focus on the chromodomain helicase DNA binding chromatin-remodeling family and the recent evidence for its deregulation in diverse pathological conditions, providing a new perspective on the underlying mechanisms and their implications for these prevalent human diseases.

Item Type: Paper
Subjects: diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > Chromatin dynamics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromatin remodeling
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > genomes
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Matt Covey
Date: August 2014
Date Deposited: 07 Nov 2014 16:01
Last Modified: 28 Apr 2015 19:24
PMCID: PMC4233650
Related URLs:
URI: http://repository.cshl.edu/id/eprint/30892

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