Upstream activation of PTEN

Naguib, A., Bencze, G., Faehnle, C. R., Schalch, T., Lazar, Z., Ruse, C. I., Joshua-Tor, L., Pappin, D. J., Trotman, L. C. (2013) Upstream activation of PTEN. Cancer Research, 73 (8 (Sup). p. 5156. ISSN 0008-5472

URL: http://cancerres.aacrjournals.org/cgi/content/shor...
DOI: 10.1158/1538-7445.am2013-5156

Abstract

The PTEN tumor suppressor is among the most frequently altered genes of cancer. PTEN suppression at the protein level is critically associated with disease since PTEN is haploinsufficient in many cancer types, including prostate. We have recently shown strong cooperation between protein phosphatases and PTEN to suppress PI 3-Kinase and AKT signaling in prostate cancer. Intriguingly, our findings showed that PTEN status orchestrates a PHLPP2 response by controlling the protein levels of this phosphatase. Yet, little is known about genes that control the levels and activity of PTEN to a degree that they critically maintain its function in disease. Therefore, it is assumed that PTEN is constitutively active in normal cells. Here we identify the upstream activation mechanism of PTEN and discuss the consequences for cancer diagnosis and therapy with PI 3-Kinase pathway inhibitors.

Item Type: Paper
Additional Information: Meeting Abstract
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > PTEN
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
diseases & disorders > cancer > cancer types > prostate cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Joshua-Tor lab
CSHL labs > Pappin lab
CSHL labs > Trotman lab
Depositing User: Matt Covey
Date Deposited: 11 Apr 2014 16:37
Last Modified: 11 Apr 2014 16:37
URI: http://repository.cshl.edu/id/eprint/29759

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