Demetrick, D. J., Matsumoto, S., Hannon, G. J., Okamoto, K., Xiong, Y., Zhang, H., Beach, D. H.
(1995)
Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).
Cytogenetics and Cell Genetics, 69 (3-4).
pp. 190-192.
ISSN 03010171 (ISSN)
Abstract
Many gene products associated with the cdk cell cycle kinases are thought to regulate the active kinase complex and thus regulate the transition points of the cell cycle. Genes encoding these proteins may potentially function as oncogenes or tumor suppressor genes. We describe the chromosomal mapping by FISH of the genes for several cdk-associated proteins including human CCNC (cyclin C) to 6q21, CCNE (cyclin E) to 19q12 → q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22). Some of these sites are near chromosomal translocations or LOH sites common to a variety of human tumors. The potential role for each of these genes in neoplasia is discussed.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
cycline
article
cell cycle
gene location
gene mapping
genetic regulation
human
human cell
mitosis
neoplasm
normal human
priority journal
Cell Cycle Proteins
Chromosome Mapping
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 19
Chromosomes, Human, Pair 6
Cyclins
In Situ Hybridization, Fluorescence
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S. |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p21 |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hannon lab |
| Depositing User: |
Matt Covey
|
| Date: |
1995 |
| Date Deposited: |
09 Jan 2013 16:59 |
| Last Modified: |
09 Jan 2013 16:59 |
| URI: |
https://repository.cshl.edu/id/eprint/26484 |
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