Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)

Demetrick, D. J., Matsumoto, S., Hannon, G. J., Okamoto, K., Xiong, Y., Zhang, H., Beach, D. H. (1995) Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). Cytogenetics and Cell Genetics, 69 (3-4). pp. 190-192. ISSN 03010171 (ISSN)

URL: http://www.ncbi.nlm.nih.gov/pubmed/7698009

Abstract

Many gene products associated with the cdk cell cycle kinases are thought to regulate the active kinase complex and thus regulate the transition points of the cell cycle. Genes encoding these proteins may potentially function as oncogenes or tumor suppressor genes. We describe the chromosomal mapping by FISH of the genes for several cdk-associated proteins including human CCNC (cyclin C) to 6q21, CCNE (cyclin E) to 19q12 → q13, CDKN1 (p21) to 6p21.2 and CDKN3 (KAP to 14q22). Some of these sites are near chromosomal translocations or LOH sites common to a variety of human tumors. The potential role for each of these genes in neoplasia is discussed.

Item Type:	Paper
Uncontrolled Keywords:	cycline article cell cycle gene location gene mapping genetic regulation human human cell mitosis neoplasm normal human priority journal Cell Cycle Proteins Chromosome Mapping Chromosomes, Human, Pair 14 Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 6 Cyclins In Situ Hybridization, Fluorescence Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p21
CSHL Authors:	Beach, David H. Hannon, Gregory J. Xiong, Yue
Communities:	CSHL labs > Hannon lab
Depositing User:	Matt Covey
Date:	1995
Date Deposited:	09 Jan 2013 16:59
Last Modified:	09 Jan 2013 16:59
URI:	https://repository.cshl.edu/id/eprint/26484

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