Hudson, J. D., Shoaibi, M. A., Maestro, R., Carnero, A., Hannon, G. J., Beach, D. H.
(1999)
A proinflammatory cytokine inhibits p53 tumor suppressor activity.
Journal of Experimental Medicine, 190 (10).
pp. 1375-1382.
ISSN 00221007 (ISSN)
Abstract
p53 has a key role in the negative regulation of cell proliferation, in the maintenance of genomic stability, and in the suppression of transformation and tumorigenesis. To identify novel regulators of p53, we undertook two functional screens to isolate genes which bypassed either p53- mediated growth arrest or apoptosis. In both screens, we isolated cDNAs encoding macrophage migration inhibitory factor (MIF), a cytokine that was shown previously to exert both local and systemic proinflammatory activities. Treatment with MIF overcame p53 activity in three different biological assays, and suppressed its activity as a transcriptional activator. The observation that a proinflammatory cytokine, MIF, is capable of functionally inactivating a tumor suppressor, p53, may provide a link between inflammation and tumorigenesis.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Apoptosis
Growth arrest
Inflammation and cancer
Macrophage migration inhibitory factor
p53
cytokine
macrophage migration inhibition factor
protein p53
animal cell
article
cancer inhibition
carcinogenesis
cell proliferation
genetic stability
growth disorder
inflammation
nonhuman
priority journal
regulatory mechanism
transactivation
Animals
Cell Line
Chronic Disease
Fibroblasts
Macrophage Migration-Inhibitory Factors
Mice
Neoplasms
Nitric Oxide
Rats
Trans-Activation (Genetics)
Tumor Suppressor Protein p53 |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
diseases & disorders > inflammation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > suppressor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hannon lab |
| Depositing User: |
Matt Covey
|
| Date: |
1999 |
| Date Deposited: |
09 Jan 2013 17:33 |
| Last Modified: |
09 Jan 2013 17:33 |
| PMCID: |
PMC2195698 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/26478 |
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