Functional homology of mammalian and yeast RAS genes

Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40 (1). pp. 19-26.

URL: https://www.ncbi.nlm.nih.gov/pubmed/2981628
DOI: 10.1016/0092-8674(85)90304-6

Abstract

Yeast spores lacking endogenous RAS genes will not germinate. If such spores contain chimeric mammalian/yeast RAS genes or even the mammalian H-ras gene under the control of the galactose-inducible GAL10 promoter, they will germinate in the presence of galactose and produce for continued growth and viability. The results indicate that the biochemical function of RAS proteins is essential for vegetative haploid yeast and that this function has been conserved in evolution since the progenitors of yeast and mammals diverged.

Item Type: Paper
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organism description > animal > mammal
organism description > yeast
CSHL Authors:
Communities: CSHL labs > Powers lab
CSHL labs > Wigler lab
Depositing User: CSHL Librarian
Date: 1985
Date Deposited: 12 Apr 2012 18:17
Last Modified: 18 Nov 2016 16:55
Related URLs:
URI: http://repository.cshl.edu/id/eprint/26206

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