Kataoka, T., Powers, S., Cameron, S., Fasano, O., Goldfarb, M., Broach, J., Wigler, M. H. (1985) Functional homology of mammalian and yeast RAS genes. Cell, 40 (1). pp. 19-26.
Abstract
Yeast spores lacking endogenous RAS genes will not germinate. If such spores contain chimeric mammalian/yeast RAS genes or even the mammalian H-ras gene under the control of the galactose-inducible GAL10 promoter, they will germinate in the presence of galactose and produce for continued growth and viability. The results indicate that the biochemical function of RAS proteins is essential for vegetative haploid yeast and that this function has been conserved in evolution since the progenitors of yeast and mammals diverged.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > RAS bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression organism description > animal > mammal organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Powers lab CSHL labs > Wigler lab |
| Depositing User: | CSHL Librarian |
| Date: | 1985 |
| Date Deposited: | 12 Apr 2012 18:17 |
| Last Modified: | 18 Nov 2016 16:55 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26206 |
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