The primacy model and the structure of olfactory space

Giaffar, Hamza, Shuvaev, Sergey, Rinberg, Dmitry, Koulakov, Alexei A (September 2024) The primacy model and the structure of olfactory space. PLoS Computational Biology, 20 (9). e1012379. ISSN 1553-734X (Public Dataset)

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URL: https://www.ncbi.nlm.nih.gov/pubmed/39255274

DOI: 10.1371/journal.pcbi.1012379

Abstract

Understanding sensory processing involves relating the stimulus space, its neural representation, and perceptual quality. In olfaction, the difficulty in establishing these links lies partly in the complexity of the underlying odor input space and perceptual responses. Based on the recently proposed primacy model for concentration invariant odor identity representation and a few assumptions, we have developed a theoretical framework for mapping the odor input space to the response properties of olfactory receptors. We analyze a geometrical structure containing odor representations in a multidimensional space of receptor affinities and describe its low-dimensional implementation, the primacy hull. We propose the implications of the primacy hull for the structure of feedforward connectivity in early olfactory networks. We test the predictions of our theory by comparing the existing receptor-ligand affinity and connectivity data obtained in the fruit fly olfactory system. We find that the Kenyon cells of the insect mushroom body integrate inputs from the high-affinity (primacy) sets of olfactory receptors in agreement with the primacy theory.

Item Type:	Paper
Subjects:	organism description > animal > insect > Drosophila organism description > animal behavior organism description > animal > insect organism description > animal behavior > olfactory
CSHL Authors:	Giaffar, Hamza Shuvaev, Sergey Koulakov, Alexei A.
Communities:	CSHL labs > Koulakov lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	10 September 2024
Date Deposited:	26 Nov 2024 15:40
Last Modified:	26 Nov 2024 15:40
PMCID:	PMC11423968
Related URLs:	Publisher
Dataset ID:	https://github.com/KoulakovLab/PrimacyModel
URI:	https://repository.cshl.edu/id/eprint/41744

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