Xu, Jihao, Roe, Jae-Seok, Lee, EunJung, Tonelli, Claudia, Somervile, Tim, Yao, Melissa, Milazzo, Joseph, Tiriac, Herve, Kolarzyk, Anna, Lee, Esak, Grem, Jeam, Lazenby, Audrey, Grunkemeyer, James, Hollingsworth, Michael, Grandgenett, Paul, Borowsky, Alexander, Park, Youngkyu, Vakoc, Christopher, Tuveson, David, Hwang, Chang-Il (January 2024) Engrailed-1 promotes pancreatic cancer metastasis. In: AACR Special Conference in Cancer Research: Pancreatic Cancer, 2023 Sep 27-30, Boston, Massachusetts.
Abstract
Engrailed-1 (EN1) is a critical homeodomain transcription factor (TF) required for neuronal survival, and EN1 expression has been shown to promote aggressive forms of triple negative breast cancer. Here, we report that EN1 is aberrantly expressed in a subset of pancreatic ductal adenocarcinoma (PDA) patients with poor outcomes. EN1 predominantly repressed its target genes through direct binding to gene enhancers and promoters, implicating a role in the acquisition of mesenchymal cell properties. Gain- and loss-of-function experiments demonstrated that EN1 promoted PDA transformation and metastasis in vitro and in vivo. Our findings nominate the targeting of EN1 and downstream pathways in aggressive PDA.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | diseases & disorders > cancer diseases & disorders diseases & disorders > cancer > metastasis diseases & disorders > cancer > cancer types > pancreatic cancer diseases & disorders > cancer > cancer types |
| CSHL Authors: | |
| Communities: | CSHL labs > Tuveson lab CSHL labs > Vakoc lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 16 January 2024 |
| Date Deposited: | 11 Mar 2024 18:03 |
| Last Modified: | 11 Mar 2024 18:03 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41462 |
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