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Number of items at this level: 36.

Paper

Tonelli, Claudia, Yordanov, Georgi N, Hao, Yuan, Deschênes, Astrid, Hinds, Juliene, Belleau, Pascal, Klingbeil, Olaf, Brosnan, Erin, Doshi, Abhishek, Park, Youngkyu, Hruban, Ralph H, Vakoc, Christopher R, Dobin, Alexander, Preall, Jonathan, Tuveson, David A (January 2024) A mucus production programme promotes classical pancreatic ductal adenocarcinoma. Gut. ISSN 0017-5749

Xu, Jihao, Roe, Jae-Seok, Lee, EunJung, Tonelli, Claudia, Ji, Keely Y, Younis, Omar W, Somervile, Tim DD, Yao, Melissa, Milazzo, Joseph P, Tiriac, Herve, Kolarzyk, Anna M, Lee, Esak, Grem, Jean L, Lazenby, Audrey J, Grunkemeyer, James A, Hollingsworth, Michael A, Grandgenett, Paul M, Borowsky, Alexander D, Park, Youngkyu, Vakoc, Christopher R, Tuveson, David A, Hwang, Chang-Il (December 2023) Engrailed-1 Promotes Pancreatic Cancer Metastasis. Advanced Science. e2308537. ISSN 2198-3844

Wan, Ledong, Lin, Kuan-Ting, Rahman, Mohammad Alinoor, Ishigami, Yuma, Wang, Zhikai, Jensen, Mads A, Wilkinson, John E, Park, Youngkyu, Tuveson, David A, Krainer, Adrian R (July 2023) Splicing Factor SRSF1 Promotes Pancreatitis and KRASG12D-Mediated Pancreatic Cancer. Cancer Discovery, 13 (7). pp. 1678-1695. ISSN 2159-8274

De Sanctis, Francesco, Lamolinara, Alessia, Boschi, Federico, Musiu, Chiara, Caligola, Simone, Trovato, Rosalinda, Fiore, Alessandra, Frusteri, Cristina, Anselmi, Cristina, Poffe, Ornella, Cestari, Tiziana, Canè, Stefania, Sartoris, Silvia, Giugno, Rosalba, Del Rosario, Giulia, Zappacosta, Barbara, Del Pizzo, Francesco, Fassan, Matteo, Dugnani, Erica, Piemonti, Lorenzo, Bottani, Emanuela, Decimo, Ilaria, Paiella, Salvatore, Salvia, Roberto, Lawlor, Rita Teresa, Corbo, Vincenzo, Park, Youngkyu, Tuveson, David A, Bassi, Claudio, Scarpa, Aldo, Iezzi, Manuela, Ugel, Stefano, Bronte, Vincenzo (January 2022) Interrupting the nitrosative stress fuels tumor-specific cytotoxic T lymphocytes in pancreatic cancer. Journal for ImmunoTherapy of Cancer, 10 (1). e003549-e003549. ISSN 2051-1426

Tonelli, Claudia, Deschênes, Astrid, Yao, Melissa, Park, Youngkyu, Tuveson, David (January 2022) Loss of p53 tumor suppression function drives invasion and genomic instability in models of murine pancreatic cancer. BioRxiv. (Unpublished)

Cheng, Derek K, Oni, Tobiloba E, Thalappillil, Jennifer S, Park, Youngkyu, Ting, Hsiu-Chi, Alagesan, Brinda, Prasad, Nadia V, Addison, Kenneth, Rivera, Keith D, Pappin, Darryl J, Van Aelst, Linda, Tuveson, David A (May 2021) Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer. Proceedings of the National Academy of Sciences of USA, 118 (21). e2016904118-e2016904118. ISSN 0027-8424

Steele, Nina G, Biffi, Giulia, Kemp, Samantha B, Zhang, Yaqing, Drouillard, Donovan, Syu, LiJyun, Hao, Yuan, Oni, Tobiloba E, Brosnan, Erin, Elyada, Ela, Doshi, Abhishek, Hansma, Christa, Espinoza, Carlos, Abbas, Ahmed, The, Stephanie, Irizarry-Negron, Valerie, Halbrook, Christopher J, Franks, Nicole E, Hoffman, Megan T, Brown, Kristee, Carpenter, Eileen S, Nwosu, Zeribe C, Johnson, Craig, Lima, Fatima, Anderson, Michelle A, Park, Youngkyu, Crawford, Howard C, Lyssiotis, Costas A, Frankel, Timothy L, Rao, Arvind, Bednar, Filip, Dlugosz, Andrzej A, Preall, Jonathan B, Tuveson, David A, Allen, Benjamin L, Pasca di Magliano, Marina (April 2021) Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer. Clinical Cancer Research, 27 (7). pp. 2023-2037. ISSN 1078-0432

Wan, Ledong, Lin, Kuan-Ting, Rahman, Mohammad Alinoor, Wang, Zhikai, Jensen, Mads, Park, Youngkyu, Tuveson, David, Krainer, Adrian (2021) Loss of KRAS G12D feedback regulation involving splicing factor SRSF1 accelerates pancreatic cancer. bioRxiv. (Submitted)

Cheng, D. K., Oni, T. E., Park, Y., Thalappillil, J. S, Ting, H.-C., Alagesan, B., Prasad, N. V., Rivera, K. D., Pappin, D. J., Van Aelst, L., Tuveson, D. A. (September 2020) Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancer. BioRxiv. (Unpublished)

Oni, T. E., Biffi, G., Baker, L. A., Hao, Y., Tonelli, C., Somerville, T. D. D., Deschênes, A., Belleau, P., Hwang, C. I., Sánchez-Rivera, F. J., Cox, H., Brosnan, E., Doshi, A., Lumia, R. P., Khaledi, K., Park, Y., Trotman, L. C., Lowe, S. W., Krasnitz, A., Vakoc, C. R., Tuveson, D. A. (July 2020) SOAT1 promotes mevalonate pathway dependency in pancreatic cancer. J Exp Med, 217 (9). ISSN 0022-1007

Moral, J.A., Leung, J., Rojas, L.A., Ruan, J., Zhao, J., Sethna, Z., Ramnarain, A., Gasmi, B., Gururajan, M., Redmond, D., Askan, G., Bhanot, U., Elyada, E., Park, Y., Tuveson, D. A., Gonen, M., Leach, S.D., Wolchok, J.D., DeMatteo, R. P., Merghoub, T., Balachandran, V. P. (February 2020) ILC2s Amplify PD-1 Blockade by Activating Tissue-Specific Cancer Immunity. Nature, 579 (7797). pp. 130-135. ISSN 0028-0836 (Public Dataset)

Froeling, F. E. M., Mosur Swamynathan, M., Deschenes, A., Chio, I. I. C., Brosnan, E., Yao, M. A., Alagesan, P., Lucito, M. S., Li, J., Chang, A. Y., Trotman, L. C., Belleau, P., Park, Y., Rogoff, H. A., Watson, J. D., Tuveson, D. A. (September 2019) Bioactivation of napabucasin triggers reactive oxygen species-mediated cancer cell death. Clin Cancer Res, 25 (23). pp. 7162-7174. ISSN 1078-0432 (Print)1078-0432

Humpton, T. J., Alagesan, B., DeNicola, G. M., Lu, D., Yordanov, G. N., Leonhardt, C. S., Yao, M. A., Alagesan, P., Zaatari, M. N., Park, Y., Skepper, J. N., Macleod, K. F., Perez-Mancera, P. A., Murphy, M. P., Evan, G. I., Vousden, K. H., Tuveson, D. A. (July 2019) Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer. Cancer Discov, 99 (9). pp. 1268-1298. ISSN 2159-8274

Engle, D. D., Tiriac, H., Rivera, K. D., Pommier, A., Whalen, S., Oni, T. E., Alagesan, B., Lee, E. J., Yao, M. A., Lucito, M. S., Spielman, B., Da Silva, B., Schoepfer, C., Wright, K., Creighton, B., Afinowicz, L., Yu, K. H., Grutzmann, R., Aust, D., Gimotty, P. A., Pollard, K. S., Hruban, R. H., Goggins, M. G., Pilarsky, C., Park, Y., Pappin, D. J., Hollingsworth, M. A., Tuveson, D. A. (June 2019) The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science, 364 (6446). pp. 1156-1162. ISSN 0036-8075

Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., Sivajothi, S., Armstrong, T. D., Engle, D. D., Yu, K. H., Hao, Y., Wolfgang, C. L., Park, Y., Preall, J., Jaffee, E. M., Califano, A., Robson, P., Tuveson, D. A. (June 2019) Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov, 9 (8). pp. 1102-1123. ISSN 2159-8274

Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., Tuveson, D. A. (October 2018) IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov, 9 (2). pp. 282-301. ISSN 2159-8274

Engle, D., Tiriac, H., Pommier, A., Schoepfer, C., Da Silva, B., Yao, M., Park, Y., Hollingsworth, M. A., Tuveson, D. (May 2018) Exploring the role of glycosylation in pancreatic diseass. Cancer Research, 78 (10 Sup). p. 44. ISSN 0008-5472

Wolff, R. A., Wang-Gillam, A., Alvarez, H., Tiriac, H., Engle, D., Hou, S., Groff, A. F., Lucas, A. S., Bernard, V., Allenson, K., Castillo, J., Kim, D., Mulu, F., Huang, J., Stephens, B., Wistuba, I. I., Katz, M., Varadhachary, G., Park, Y., Hicks, J., Chinnaiyan, A., Scampavia, L., Spicer, T., Gerhardinger, C., Maitra, A., Tuveson, D., Rinn, J., Lizee, G., Yee, C., Levine, A. J. (March 2018) Dynamic changes during the treatment of pancreatic cancer. Oncotarget, 9 (19). pp. 14764-14790. ISSN 1949-2553

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M., Egeblad, M., Park, Y., Tuveson, D. A., Vakoc, C. R. (August 2017) Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis. Cell, 170 (5). pp. 875-888. ISSN 0092-8674

Sinha, S., Fu, Y. Y., Grimont, A., Ketcham, M., Lafaro, K. J., Saglimbeni, J. A., Askan, G., Bailey, J. M., Melchor, J. P., Zhong, Y., Joo, M. G., Grbovic-Huezo, O., Yang, I. H., Basturk, O., Baker, L., Park, Y., Kurtz, R. C., Tuveson, D. A., Leach, S. D., Pasricha, P. (April 2017) PanIN neuroendocrine cells promote tumorigenesis via neuronal crosstalk. Cancer Res, 77 (8). pp. 1868-1879. ISSN 1538-7445 (Electronic)0008-5472 (Linking)

Ohlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., Chio, II, Hwang, C. I., Tiriac, H., Baker, L. A., Engle, D. D., Feig, C., Kultti, A., Egeblad, M., Fearon, D. T., Crawford, J. M., Clevers, H., Park, Y., Tuveson, D. A. (March 2017) Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med, 214 (3). pp. 579-596. ISSN 0022-1007

Chio, I. I. C., Jafarnejad, S. M., Ponz-Sarvise, M., Park, Y., Rivera, K., Palm, W., Ohlund, D., Hammell, M., Crawford, H., Schmidt, E., Thompson, C., Pappin, D., Sonenberg, N., Tuveson, D. (March 2017) NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer. Cancer Research, 77 (Supple). ISSN 0008-54721538-7445

Chio, Iok In Christine, Jafarnejad, Seyed Mehdi, Ponz-Sarvise, Mariano, Park, Youngkyu, Rivera, Keith, Palm, Wilhelm, Wilson, John, Sangar, Vineet, Hao, Yuan, Öhlund, Daniel, Wright, Kevin, Filippini, Dea, Lee, Eun Jung, Da Silva, Brandon, Schoepfer, Christina, Wilkinson, John Erby, Buscaglia, Jonathan M, DeNicola, Gina M, Tiriac, Herve, Hammell, Molly, Crawford, Howard C, Schmidt, Edward E, Thompson, Craig B, Pappin, Darryl J, Sonenberg, Nahum, Tuveson, David A (August 2016) NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer. Cell, 166 (4). pp. 963-976. ISSN 0092-8674

Palm, W., Park, Y., Wright, K., Pavlova, N. N., Tuveson, D. A., Thompson, C. B. (July 2015) The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1. Cell, 162 (2). pp. 259-270. ISSN 1097-4172 (Electronic)0092-8674 (Linking)

Boj, Sylvia F, Hwang, Chang-Il, Baker, Lindsey A, Chio, Iok In Christine, Engle, Dannielle D, Corbo, Vincenzo, Jager, Myrthe, Ponz-Sarvise, Mariano, Tiriac, Hervé, Spector, Mona S, Gracanin, Ana, Oni, Tobiloba, Yu, Kenneth H, van Boxtel, Ruben, Huch, Meritxell, Rivera, Keith D, Wilson, John P, Feigin, Michael E, Öhlund, Daniel, Handly-Santana, Abram, Ardito-Abraham, Christine M, Ludwig, Michael, Elyada, Ela, Alagesan, Brinda, Biffi, Giulia, Yordanov, Georgi N, Delcuze, Bethany, Creighton, Brianna, Wright, Kevin, Park, Youngkyu, Morsink, Folkert H M., Molenaar, I.  Quintus, Borel Rinkes, Inne H, Cuppen, Edwin, Hao, Yuan, Jin, Ying, Nijman, Isaac J, Iacobuzio-Donahue, Christine, Leach, Steven D, Pappin, Darryl J, Hammell, Molly, Klimstra, David S, Basturk, Olca, Hruban, Ralph H, Offerhaus, George Johan, Vries, Robert G J., Clevers, Hans, Tuveson, David A (January 2015) Organoid Models of Human and Mouse Ductal Pancreatic Cancer. Cell, 160 (1-2). pp. 324-338. ISSN 0092-8674

Ponz-Sarvise, M., Corbo, V., Ohlund, D., Oni, T., Handly-Santana, A., Engle, D., Tiriac, H., Chio, C., Feigin, M., Baker, L., Ardito-Abraham, C., Park, Y., Hwang, C., Elyada, E., Yu, K., Clevers, H., Tuveson, D. A. (November 2014) Pancreatic ductal organoids as a new platform for drug discovery. European Journal of Cancer, 50. p. 63. ISSN 0959-8049

Mazurek, A., Park, Y., Miething, C., Wilkinson, J. E., Gillis, J., Lowe, S. W, Vakoc, C. R, Stillman, B. (June 2014) Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5. Cell Reports, 7 (6). pp. 1887-1899. ISSN 2211-1247

Conference or Workshop Item

Demyan, Lyudmyla, Standring, Oliver, Chung, Taemoon, Gazzara, Emma, Lyons, Scott, Park, Youngkyu, King, Daniel, Jonas, Oliver, Tuveson, David, Weiss, Matthew (2023) Feasibility of Implantable Microdosing Devices to Perform in vivo Pharmacotyping in Pancreatic Cancer. In: Annual International Conference of the Society-of-Surgical-Oncology (SSO) on Surgical Cancer Care, MAR 22-25, 2023, Boston, MA.

Stevens, Payton D, Sall, Emily, Zhong, Alex, Hostetter, Galen, Madaj, Zachary, Thalappillil, Jennifer, Dobin, Alexander, Park, Youngkyu, Tuveson, David A, Williams, Bart O (2022) FZD6 and RYK, non-canonical Wnt receptors in pancreatic cancer progression. In: Annual Meeting of the American-Association-for-Cancer-Research (AACR), APR 08-13, 2022, New Orleans, LA.

Caligiuri, Giuseppina, Thalappillil, Jennifer S, Shakiba, Mojdeh, Nadella, Sandeep, Hinds, Juliene, Courtois, Elise, Flynn, William F, Alagesan, Brinda, Yordanov, Georgi N, Kaminow, Benjamin, Robson, Paul, Perez-Mancera, Pedro A, Preall, Jonathan, Dobin, Alexander, Park, Youngku, Tuveson, David A (2022) Oncogenic KRAS signaling drives the activation of tissue-resident fibroblasts and is required to maintain CAF heterogeneity in pancreatic cancer. In: AACR Special Conference on Pancreatic Cancer, 2022 Sep 13-16, Boston, MA.

Thalappillil, Jennifer S, Caligiuri, Giuseppina, Nadella, Sandeep, Alagesan, Brinda, Yordanov, Georgi N, Shakiba, Mojdeh, Kaminow, Benjamin, Hinds, Juliene, Perez-Mancera, Pedro A, Preall, Jonathan, Dobin, Alexander, Park, Youngkyu, Tuveson, David A (2022) Oncogenic Kras drives cancer-associated fibroblast heterogeneity and substate changes in pancreatic cancer. In: American Association for Cancer Research Annual Meeting 2022, 2022 Apr 8-13, Philadelphia, PA.

Caligiuri, Giuseppina, Thalappillil, Jennifer, Hinds, Juliene, Courtois, Elise T, Flynn, William F, Robson, Paul, Dobin, Alexander, Park, Youngkyu, Tuveson, David A (2022) Spatial transcriptomics reveals heterogeneity and pathway dependencies of cancer associated fibroblasts in pancreatic ductal adenocarcinoma. In: Annual Meeting of the American-Association-for-Cancer-Research (AACR), APR 08-13, 2022, New Orleans, LA.

Tonelli, Claudia, Yordanov, Georgi N, Hao, Yuan, Deschenes, Astrid, Brosnan, Erin, Doshi, Abishek, Park, Youngkyu, Preall, Jonathan, Tuveson, David A (2022) The transcription factor SPDEF promotes the survival of mucinous pancreatic ductal adenocarcinoma of the classical subtype. In: American Association for Cancer Research Annual Meeting 2022, 2022 Apr 8-13, Philadelphia, PA.

Wan, Ledong, Lin, Kuan-Ting, Rahman, Mohammad A, Wang, Zhikai, Park, Youngkyu, Tuveson, David A, Krainer, Adrian R (November 2021) Loss of compensatory feedback mechanism involving splicing factor SRSF1 accelerates Kras(G12D)-mediated pancreatic cancer initiation. In: AACR Virtual Special Conference on Pancreatic Cancer.

Steele, Nina G, Biffi, Giulia, Kemp, Samantha, Zhang, Yaqing, Drouillard, Donovan, Syu, LiJyun, Hao, Yuan, Oni, Tobiloba, Brosnan, Erin, Elyada, Ela, Doshi, Abhishek, Hansma, Christa, Espinoza, Carlos, Abbas, Ahmed, The, Stephanie, Irizarry-Negron, Valerie, Halbrook, Christopher, Franks, Nicole, Hoffman, Megan, Carpenter, Eileen, Nwosu, Zeribe, Park, Youngkyu, Crawford, Howard, Lyssiotis, Costas, Frankel, Timothy, Rao, Arvind, Bednar, Filip, Dlugosz, Andrzej, Preall, Jonathan, Tuveson, David, Allen, Benjamin, Di Magliano, Marina Pasca (July 2021) Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. In: AACR Annual Meeting 2021.

Hwang, Chang-il, Roe, Jae-Seok, Lee, Eun Jung, Tonelli, Claudia, Somervile, Tim DD, Yao, Melissa, Milazzo, Joseph P, Tiriac, Herve, Park, Youngkyu, Vakoc, Christopher, Tuveson, David (December 2019) Engrailed-1 promotes pancreatic cancer progression via antagonizing COMPASS activity. In: AACR Special Conference on Pancreatic Cancer - Advances in Science and Clinical Care.

This list was generated on Wed Feb 21 16:06:02 2024 EST.
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