A race model for singular olfactory receptor expression

Kolterman, Brian E, Iossifov, Ivan, Koulakov, Alexei A (January 2012) A race model for singular olfactory receptor expression. (Submitted)

[thumbnail of 1201.2933v1.pdf] PDF
1201.2933v1.pdf - Submitted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (983kB)


In vertebrates, olfactory sensory neurons choose only one olfactory receptor to produce out of ~2000 possibilities. The mechanism for how this singular receptor expression occurs is unknown. Here we propose a mechanism that can stochastically select a single gene out of a large number of possibilities. In this model, receptor genes compete for a limited pool of transcription factors (TFs). The gene that recruits a target number of TFs is selected for expression. To support this mechanism, we have attempted to detect repeated motifs within known sequences of mouse olfactory receptor promoters. We find motifs that are significantly overrepresented in olfactory versus other gene promoters. We identify possible TFs that can target these motifs. Our model suggests that a small number of TFs can control the selection of a single gene out of ~2000 possibilities.

Item Type: Paper
Subjects: organism description > animal behavior > olfactory
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
CSHL Authors:
Communities: CSHL labs > Iossifov lab
CSHL labs > Koulakov lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 13 January 2012
Date Deposited: 13 Oct 2023 14:21
Last Modified: 13 Oct 2023 14:21
Related URLs:
URI: https://repository.cshl.edu/id/eprint/41227

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving