Kolterman, Brian E, Iossifov, Ivan, Koulakov, Alexei A (January 2012) A race model for singular olfactory receptor expression. (Submitted)
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Abstract
In vertebrates, olfactory sensory neurons choose only one olfactory receptor to produce out of ~2000 possibilities. The mechanism for how this singular receptor expression occurs is unknown. Here we propose a mechanism that can stochastically select a single gene out of a large number of possibilities. In this model, receptor genes compete for a limited pool of transcription factors (TFs). The gene that recruits a target number of TFs is selected for expression. To support this mechanism, we have attempted to detect repeated motifs within known sequences of mouse olfactory receptor promoters. We find motifs that are significantly overrepresented in olfactory versus other gene promoters. We identify possible TFs that can target these motifs. Our model suggests that a small number of TFs can control the selection of a single gene out of ~2000 possibilities.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal behavior > olfactory bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Iossifov lab CSHL labs > Koulakov lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 13 January 2012 |
| Date Deposited: | 13 Oct 2023 14:21 |
| Last Modified: | 13 Oct 2023 14:21 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/41227 |
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