Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity

Zeraati, Roxana, Shi, Yan-Liang, Steinmetz, Nicholas A, Gieselmann, Marc A, Thiele, Alexander, Moore, Tirin, Levina, Anna, Engel, Tatiana A (April 2023) Intrinsic timescales in the visual cortex change with selective attention and reflect spatial connectivity. Nature Communications, 14 (1). p. 1858. ISSN 2041-1723

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Abstract

Intrinsic timescales characterize dynamics of endogenous fluctuations in neural activity. Variation of intrinsic timescales across the neocortex reflects functional specialization of cortical areas, but less is known about how intrinsic timescales change during cognitive tasks. We measured intrinsic timescales of local spiking activity within columns of area V4 in male monkeys performing spatial attention tasks. The ongoing spiking activity unfolded across at least two distinct timescales, fast and slow. The slow timescale increased when monkeys attended to the receptive fields location and correlated with reaction times. By evaluating predictions of several network models, we found that spatiotemporal correlations in V4 activity were best explained by the model in which multiple timescales arise from recurrent interactions shaped by spatially arranged connectivity, and attentional modulation of timescales results from an increase in the efficacy of recurrent interactions. Our results suggest that multiple timescales may arise from the spatial connectivity in the visual cortex and flexibly change with the cognitive state due to dynamic effective interactions between neurons.

Item Type:	Paper
Subjects:	organism description > animal organism description > animal behavior organism description > animal behavior > attention organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organism description > animal > mammal organism description > animal > mammal > primates > monkey organs, tissues, organelles, cell types and functions > tissues types and functions > neural networks organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions organism description > animal > mammal > primates organs, tissues, organelles, cell types and functions > tissues types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	Engel, Tatiana Shi, Yan-Liang
Communities:	CSHL labs > Engel lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	3 April 2023
Date Deposited:	20 Apr 2023 19:12
Last Modified:	11 Jan 2024 15:07
PMCID:	PMC10070246
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/40882

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