Benoit, Matthias (January 2022) Hot 'n cold: Applying the cis-regulatory code to predict heat and cold stress response in maize. The Plant cell, 34 (1). pp. 497-498. ISSN 1532-298X
Abstract
Plant development entails strictly regulated transcriptional programs, broadly dictated by regulatory DNA that determines spatiotemporal patterns of gene expression. Plants have developed a remarkable adaptability to fluctuating environments, relying on a large repertoire of regulatory mechanisms that orchestrates transcriptional reprogramming and adaptation (Nakashima et al., 2009). Although the core transcriptional stress response is thought to be conserved within a species, remarkable examples of local adaptation revealed highly variable, genotype-specific response to stresses that have been linked to cis-regulatory variation (Lasky et al., 2014). Nevertheless, our ability to decode the cis-regulatory elements (CREs) underlying the transcriptional response to environmental stresses, and to predict gene expression patterns from these cis-regulatory signatures alone, remain limited.
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