Awaad, Amani S, Al-Jaber, Nabilah A, Moses, John E, El-Meligy, Reham M, Zain, Mohamed E (January 2013) Antiulcerogenic activities of the extracts and isolated flavonoids of Euphorbia cuneata Vahl. Phytotherapy Research, 27 (1). pp. 126-130. ISSN 0951-418X
Abstract
The total alcohol extracts of Euphorbia cuneata Vahl.(Euphorbiaceae) were screened for antiulcerogenic activity using an ethanol-induced ulcer model at doses of 125, 250 and 500 mg/kg. The extracts possessed antiulcerogenic activity in a dose-dependent manner. Four flavonoidal compounds were isolated and identified as naringenin, aromadendrin, apigenin and 4'-O-methoxy-luteolin-7-O-rhamnoglucoside, each demonstrating antiulcerogenic activity with curative ratios ranging from 75.78% to 88.23%. In addition, the alcohol extracts and isolated compounds were shown to scavenge the 1,1-diphenyl,2-picrylhydrazyl radical by different ratio, with the most effective being 4'-O-methoxy-luteolin-7-O-rhamnoglucoside (91.14%). The antioxidant activity of the alcohol extracts and the isolated compounds may explain the antiulcerogenic properties. No side effects were observed on either liver or kidney functions.
| Item Type: | Paper |
|---|---|
| Subjects: | chemistry organism description > plant diseases & disorders > ulcer |
| CSHL Authors: | |
| Communities: | CSHL labs > Moses lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | January 2013 |
| Date Deposited: | 02 Jul 2021 18:23 |
| Last Modified: | 02 Jul 2021 18:23 |
| URI: | https://repository.cshl.edu/id/eprint/40244 |
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