Wigler, MH (January 2017) The ras system in yeasts. In: The ras Superfamily of GTPases. CRC Press, pp. 155-172. ISBN 9781138105126
Abstract
The ras oncogenes are highly conserved in evolution. Homologs of these genes have been found in many eukaryotes, including unicellular 18, 23, 32, 75, 78 and complex multicellular organisms. 26, 40 70 It is likely that ras homologs will be found in all eukaryotic organisms. Certainly there are no other oncogenes presently known that are as highly conserved. The degree of identify between the mammalian oncogenic RAS proteins and the RAS proteins of the yeasts Saccharomyces cerevisiae (RASI and RAS2) and Schizosaccharomyces pombe (ras1) in the N terminal halves of the molecules is about 90%. To put this into perspective, the degree of identity between the cAMP-dependent protein kinase regulatory subunits from yeasts and mammals is in the range of 50%. 95 These subunits bind two molecules of cAMP apiece, dimerize, bind the catalytic sub-unit, release the catalytic subunit from inhibition upon binding cAMP, and retain the ability to interact with the catalytic subunit of the divergent organisms. 42, 111 From this example it is reasonable to infer that the level of conservation of primary structure observed for RAS is associated with the conservation of many biochemical functions. This inference is correct.
| Item Type: | Book Section |
|---|---|
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogenes organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Wigler lab |
| SWORD Depositor: | CSHL Elements |
| Depositing User: | CSHL Elements |
| Date: | 1 January 2017 |
| Date Deposited: | 06 May 2021 19:25 |
| Last Modified: | 06 May 2021 19:25 |
| URI: | https://repository.cshl.edu/id/eprint/40030 |
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