Deconstructing tumor heterogeneity: the stromal perspective.

Vickman, Renee E, Faget, Douglas V, Beachy, Philip, Beebe, David, Bhowmick, Neil A, Cukierman, Edna, Deng, Wu-Min, Granneman, James G, Hildesheim, Jeffrey, Kalluri, Raghu, Lau, Ken S, Lengyel, Ernst, Lundeberg, Joakim, Moscat, Jorge, Nelson, Peter S, Pietras, Kristian, Politi, Katerina, Puré, Ellen, Scherz-Shouval, Ruth, Sherman, Mara H, Tuveson, David, Weeraratna, Ashani T, White, Richard M, Wong, Melissa H, Woodhouse, Elisa C, Zheng, Ying, Hayward, Simon W, Stewart, Sheila A (October 2020) Deconstructing tumor heterogeneity: the stromal perspective. Oncotarget, 11 (40). pp. 3621-3632. ISSN 1949-2553

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Abstract

Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive versus suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field.

Item Type:	Paper
Subjects:	bioinformatics diseases & disorders > cancer diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification diseases & disorders > cancer > drugs and therapies bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > extracellular matrix proteins bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types diseases & disorders > cancer > drugs and therapies > tumor microenvironment
CSHL Authors:	Tuveson, David A.
Communities:	CSHL labs > Tuveson lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	6 October 2020
Date Deposited:	06 May 2021 18:26
Last Modified:	01 Feb 2024 19:11
PMCID:	PMC7546755
URI:	https://repository.cshl.edu/id/eprint/40021

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