SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease.

Wang, Pengfei, Liu, Lihong, Nair, Manoj S, Yin, Michael T, Luo, Yang, Wang, Qian, Yuan, Ting, Mori, Kanako, Solis, Axel Guzman, Yamashita, Masahiro, Garg, Ankur, Purpura, Lawrence J, Laracy, Justin C, Yu, Jian, Joshua-Tor, Leemor, Sodroski, Joseph, Huang, Yaoxing, Ho, David D (December 2020) SARS-CoV-2 neutralizing antibody responses are more robust in patients with severe disease. Emerging Microbes and Infections, 9 (1). pp. 2091-2093. ISSN 2222-1751

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Abstract

We studied plasma antibody responses of 35 patients about 1 month after SARS-CoV-2 infection. Titers of antibodies binding to the viral nucleocapsid and spike proteins were significantly higher in patients with severe disease. Likewise, mean antibody neutralization titers against SARS-CoV-2 pseudovirus and live virus were higher in the sicker patients, by ∼5-fold and ∼7-fold, respectively. These findings have important implications for those pursuing plasma therapy, isolation of neutralizing monoclonal antibodies, and determinants of immunity.

Item Type:	Paper
Subjects:	diseases & disorders diseases & disorders > viral diseases diseases & disorders > viral diseases > coronavirus diseases & disorders > viral diseases > coronavirus > covid 19 organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > immunity
CSHL Authors:	Joshua-Tor, Leemor Garg, Ankur
Communities:	CSHL labs > Joshua-Tor lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	December 2020
Date Deposited:	06 May 2021 15:15
Last Modified:	01 Feb 2024 19:19
PMCID:	PMC7534308
URI:	https://repository.cshl.edu/id/eprint/40003

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