Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

Halevy, O., Novitch, B. G., Spicer, D. B., Skapek, S. X., Rhee, J., Hannon, G. J., Beach, D., Lassar, A. B. (1995) Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science, 267 (5200). pp. 1018-1021. ISSN 00368075 (ISSN)



Skeletal muscle differentiation entails the coordination of muscle-specific gene expression and terminal withdrawal from the cell cycle. This cell cycle arrest in the G, phase requires the retinoblastoma tumor suppressor protein (Rb). The function of Rb is negatively regulated by cyclin-dependent kinases (Cdks), which are controlled by Cdk inhibitors. Expression of MyoD, a skeletal muscle-specific transcriptional regulator, activated the expression of the Cdk inhibitor p21 during differentiation of murine myocytes and in nonmyogenic cells. MyoD-mediated induction of p21 did not require the tumor suppressor protein p53 and correlated with cell cycle withdrawal. Thus, MyoD may induce terminal cell cycle arrest during skeletal muscle differentiation by increasing the expression of p21.

Item Type: Paper
Uncontrolled Keywords: cyclin dependent kinase enzyme inhibitor muscle protein myod protein protein p21 transcription factor animal cell article cell cycle controlled study gene induction mitosis inhibition mouse muscle cell muscle development nonhuman priority journal skeletal muscle Animal Cell Differentiation Cell Line Cyclin-Dependent Kinases Cyclins G0 Phase Human Mice Microtubule-Associated Proteins Muscle, Skeletal Protein p53 Retinoblastoma Protein RNA, Messenger Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Transcription Factors Tumor Cells, Cultured
Subjects: organism description > animal
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organism description > animal > mammal > primates > hominids > human
organism description > animal > mammal > rodent > mouse
diseases & disorders > cancer > cancer types > retinoblastoma
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor
CSHL Authors:
Communities: CSHL labs > Beach lab
CSHL labs > Hannon lab
Depositing User: Jessica Koos
Date: 1995
Date Deposited: 11 Aug 2014 16:23
Last Modified: 11 Aug 2014 16:23
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