Galaktionov, K., Chen, X., Beach, D. (August 1996) Cdc25 cell-cycle phosphatase as a target of c-myc. Nature, 382 (6591). pp. 511-7. ISSN 0028-0836 (Print)
DOI: 10.1038/382511a0
Abstract
The product of the proto-oncogene c-myc, in partnership with Max, forms a transcription factor that can promote either oncogenic transformation or apoptosis. The Myc/Max heterodimer binds to elements in the cdc25A gene and activates transcription. Like myc, cdc25A, itself a proto-oncogene, can induce apoptosis in cells depleted of growth factor, and Myc-induced apoptosis also requires cdc25A. These findings indicate that cdc25A is a physiologically relevant transcriptional target of c-myc.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | 3T3 Cells Animals Apoptosis/genetics Binding Sites Cell Cycle Proteins/ genetics/metabolism Cell Line Cell Transformation, Neoplastic/genetics Cloning, Molecular Dna Gene Expression Regulation Humans Mice Molecular Sequence Data Phosphoprotein Phosphatase/ genetics/metabolism Protein Binding Proto-Oncogene Proteins c-myc/ metabolism RNA, Messenger/metabolism Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Transcription, Genetic cdc25 Phosphatase |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > Myc organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs > Beach lab |
| Depositing User: | Matt Covey |
| Date: | 8 August 1996 |
| Date Deposited: | 22 May 2014 18:36 |
| Last Modified: | 22 May 2014 18:36 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/30156 |
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