Sun, P., Dong, P., Dai, K., Hannon, G. J., Beach, D.
(December 1998)
p53-independent role of MDM2 in TGF-beta1 resistance.
Science, 282 (5397).
pp. 2270-2.
ISSN 0036-8075 (Print)
Abstract
Transforming growth factor-beta (TGF-beta) inhibits cell proliferation, and acquisition of TGF-beta resistance has been linked to tumorigenesis. A genetic screen was performed to identify complementary DNAs that abrogated TGF-beta sensitivity in mink lung epithelial cells. Ectopic expression of murine double minute 2 rescued TGF-beta-induced growth arrest in a p53-independent manner by interference with retinoblastoma susceptibility gene product (Rb)/E2F function. In human breast tumor cells, increased MDM2 expression levels correlated with TGF-beta resistance. Thus, MDM2 may confer TGF-beta resistance in a subset of tumors and may promote tumorigenesis by interference with two independent tumor suppressors, p53 and Rb.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animals
Breast Neoplasms/genetics/metabolism/pathology
Carrier Proteins
Cell Cycle Proteins
Cell Division
Cell Line
Cell Transformation, Neoplastic
DNA-Binding Proteins
Drug Resistance, Neoplasm
E2F Transcription Factors
Gene Expression
Genes, Retinoblastoma
Genes, p53
Genetic Vectors
Humans
Mice
Mink
Nuclear Proteins
Phosphorylation
Proto-Oncogene Proteins/genetics/ physiology
Proto-Oncogene Proteins c-mdm2
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Retinoblastoma Protein/metabolism
Signal Transduction
Transcription Factor DP1
Transcription Factors/genetics/metabolism
Transcription, Genetic
Transforming Growth Factor beta/ pharmacology/physiology
Tumor Cells, Cultured
Tumor Suppressor Protein p53/ physiology |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > MDM2
diseases & disorders > cancer > cancer types > breast cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell division
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > cell line
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hannon lab
CSHL labs > Beach lab |
| Depositing User: |
Kathleen Darby
|
| Date: |
18 December 1998 |
| Date Deposited: |
01 May 2014 12:53 |
| Last Modified: |
07 May 2014 13:01 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29935 |
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