Neel, B. G., Tonks, N. K.
(April 1997)
Protein tyrosine phosphatases in signal transduction.
Current Opinion in Cell Biology, 9 (2).
pp. 193-204.
ISSN 0955-0674
Abstract
Protein-tyrosyl phosphorylation, regulated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs), is a key cellular control mechanism. Until recently, little was known about PTPs. However, the past two years have witnessed an explosion of information about PTP structure, regulation and function. Crystal structures of several PTPs have provided insights into enzymatic mechanisms and regulation and suggested the design of 'substrate-trapping' mutants. Candidate homophilic and heterophilic ligands for transmembrane PTPs have been identified, and roles for transmembrane PTPs in regulating cell-cell interactions have been suggested. Finally, progress has been made in understanding signaling by Sro homology 2 domain containing PTPs and PTPs controlling yeast osmoregulatory pathways.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
HEMATOPOIETIC-CELL PHOSPHATASE
MAP KINASE
FISSION YEAST
NEGATIVE
REGULATION
CRYSTAL-STRUCTURE
RECEPTOR
INSULIN
DOMAIN
ACTIVATION
CD22 |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
biotechnology > chromatography > protein purification
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation > transduction
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
Investigative techniques and equipment > x ray crystallography
organism description > yeast |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Tonks lab
CSHL Cancer Center Program > Cellular Communication in Cancer Program |
| Depositing User: |
Matt Covey
|
| Date: |
April 1997 |
| Date Deposited: |
18 Dec 2013 15:39 |
| Last Modified: |
26 Oct 2020 16:14 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29040 |
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