Li, J., Simpson, L., Takahashi, M., Miliaresis, C., Myers, M. P., Tonks, N., Parsons, R.
(December 1998)
The PTEN/MMAC1 tumor suppressor induces cell death that is rescued by the AKT/protein kinase B oncogene.
Cancer Research, 58 (24).
pp. 5667-5672.
ISSN 0008-5472
Abstract
PTEN/MMAC1 is a tumor suppressor gene that is mutated in a variety of cancers. PTEN encodes a phosphatase that recognizes phosphoprotein substrates and the phospholipid, phosphatidylinositol-3,4,5-triphosphate. PTEN inhibited cell growth and/or colony formation in all of the epithelial Lines tested with one exception. The decrease in cellular proliferation was associated with an induction of apoptosis and an inhibition of signaling through the phosphatidylinositol 3'-kinase pathway. Akt/protein kinase B, a gene whose antiapoptotic function is regulated by phosphatidylinositol-3,4,5-triphosphate, was able to rescue cells from PTEN-dependent death. PTEN, therefore, appears to suppress tumor growth by regulating phosphatidylinositol 3'-kinase signaling.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
PROTEIN-KINASE
APOPTOSIS
PHOSPHATASE
GROWTH
PTEN
GENE
ACTIVATION
MUTATIONS
PATHWAYS
DOMAIN |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > PTEN
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > kinase
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > tumor suppressor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Tonks lab |
| Depositing User: |
Matt Covey
|
| Date: |
December 1998 |
| Date Deposited: |
18 Dec 2013 17:21 |
| Last Modified: |
18 Dec 2013 17:21 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/29032 |
Actions (login required)
 |
Administrator's edit/view item |
