McMullen, M. D., Kresovich, S., Villeda, Hector S., Bradbury, P. J., Li, H., Sun, Q., Flint-Garcia, S., Thornsberry, J., Acharya, C. B., Bottoms, C., Brown, P. J., Browne, C., Eller, M., Guill, K., Harjes, C., Kroon, D. E., Lepak, N.., Mitchell, S. E., Peterson, B., Pressoir, G., Romero, S., Rosas, M. O., Salvo, S., Yates, H., Hanson, M., Jones, E. G., Smith, S., Glaubitz, J. C., Goodman, M. M., Ware, D. H., Holland, J. B., Buckler, E. S. (August 2009) Genetic Properties of the Maize Nested Association Mapping Population. Science, 325 (5941). pp. 737-740.
Abstract
Maize genetic diversity has been used to understand the molecular basis of phenotypic variation and to improve agricultural efficiency and sustainability. We crossed 25 diverse inbred maize lines to the B73 reference line, capturing a total of 136,000 recombination events. Variation for recombination frequencies was observed among families, influenced by local (cis) genetic variation. We identified evidence for numerous minor single-locus effects but little two-locus linkage disequilibrium or segregation distortion, which indicated a limited role for genes with large effects and epistatic interactions on fitness. We observed excess residual heterozygosity in pericentromeric regions, which suggested that selection in inbred lines has been less efficient in these regions because of reduced recombination frequency. This implies that pericentromeric regions may contribute disproportionally to heterosis.
| Item Type: | Paper |
|---|---|
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > plant > maize bioinformatics > genomics and proteomics > Mapping and Rendering bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function organism description > plant |
| CSHL Authors: | |
| Communities: | CSHL labs > Ware lab |
| Depositing User: | Matt Covey |
| Date: | 7 August 2009 |
| Date Deposited: | 21 Feb 2013 14:35 |
| Last Modified: | 21 Feb 2013 14:35 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27386 |
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