Gamma Neurons Mediate Dopaminergic Input during Aversive Olfactory Memory Formation in Drosophila

Qin, Hongtao, Cressy, Michael, Li, Wanhe, Coravos, Jonathan S, Izzi, Stephanie A, Dubnau, Joshua (April 2012) Gamma Neurons Mediate Dopaminergic Input during Aversive Olfactory Memory Formation in Drosophila. Current Biology, 22 (7). pp. 608-614. ISSN 0960-9822

URL: http://www.ncbi.nlm.nih.gov/pubmed/22425153

DOI: 10.1016/j.cub.2012.02.014

Abstract

Summary Mushroom body (MB)-dependent olfactory learning in Drosophila provides a powerful model to investigate memory mechanisms. MBs integrate olfactory conditioned stimulus (CS) inputs with neuromodulatory reinforcement (unconditioned stimuli, US) [1, 2], which for aversive learning is thought to rely on dopaminergic (DA) signaling [3–6] to DopR, a D1-like dopamine receptor expressed in MBs [7, 8]. A wealth of evidence suggests the conclusion that parallel and independent signaling occurs downstream of DopR within two MB neuron cell types, with each supporting half of memory performance. For instance, expression of the Rutabaga (Rut) adenylyl cyclase in γ neurons is sufficient to restore normal learning to rut mutants [9], whereas expression of Neurofibromatosis 1 (NF1) in α/β neurons is sufficient to rescue NF1 mutants [10, 11]. DopR mutations are the only case where memory performance is fully eliminated [7], consistent with the hypothesis that DopR receives the US inputs for both γ and α/β lobe traces. We demonstrate, however, that DopR expression in γ neurons is sufficient to fully support short- and long-term memory. We argue that DA-mediated CS-US association is formed in γ neurons followed by communication between γ and α/β neurons to drive consolidation.

Item Type:	Paper
Subjects:	organism description > animal > insect > Drosophila organism description > animal organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > dopaminergic neuron organism description > animal > insect organism description > animal behavior > olfactory organs, tissues, organelles, cell types and functions > tissues types and functions > olfactory bulb organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Coravos, Jonathan S. Cressy, Michael Dubnau, Josh T. Li, Wanhe Qin, Hongtao
Communities:	CSHL labs > Dubnau lab CSHL Post Doctoral Fellows
Depositing User:	Matt Covey
Date:	April 2012
Date Deposited:	29 Jan 2013 17:14
Last Modified:	03 May 2013 13:57
PMCID:	PMC3326180
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27024

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